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ProteomicsHuman LC-MS, TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway
Immunopurification and mass spectrometry analysis of TMEM216-associated proteins. Cellular extracts from Flag-TMEM216-expressing 293FT cells were affinity-purified. The eluates were resolved by SDS-PAGE and stained with Coomassie Brilliant Blue. The protein bands were retrieved and analyzed by mass ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD061739 | Pride
Human 293ft cells 
UnknownGSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions.
Not available
S-EPMC6251088 | biostudies-literature
ProteomicsS-nitrosylated cysteine residues identification in Staphylococcus aureus XN108
Staphylococcus aureus is a major human pathogen that causes diverse severe infections. The emergence of multi-drug resistance has caused S. aureus infection a global concern, especially resistance to vancomycin, a drug of last resort. A growing body of research focuses on the resistance mechanisms a...
ORGANISM(S): Staphylococcus Aureus 
2023-03-27 | PXD041143 |
ProteomicsMatrix Stiffness-Driven Cytoskeletal Remodeling and Tumor Progression in Anaplastic Thyroid Cancer via Integrin-Focal Adhesion Kinase Signaling
Anaplastic thyroid cancer (ATC) is a highly lethal malignancy characterized by rapid progression and therapeutic resistance. This study uncovers the pivotal role of extracellular matrix (ECM) stiffness in driving ATC aggressiveness through mechanotransduction mediated by the Integrin α6β4/Focal Adhe...
ORGANISM(S): Homo Sapiens 
2025-08-07 | PXD067033 |
ProteomicsRheb and TRF1 PhastID mass spectrometric data
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies, the guanine nucleotide exchange factor (GEF) that directly activates Rhe...
ORGANISM(S): Homo Sapiens 
2022-09-29 | PXD037078 |
Proteomics[HPP-2.0] Proteomics data of cancers
proteomics data of multiple types of cancer including gatric, prostate, liver, thyoid, leukemia, bone, ovarian, cervical and lung tumors
ORGANISM(S): Homo Sapiens 
2024-02-02 | PXD049145 |
Proteomics4D label-free quantitative proteomics analysis of collagen-induced arthritis rats
4D label-free quantitative proteomics was performed to analysis the changes of protein expression in synovial tissues between Normal control group, Model control group and JTQBG treated group.
ORGANISM(S): Rattus Norvegicus 
2024-02-23 | PXD050056 |
ProteomicsIdentification and sequencing of CD36 interacting proteins in cardiomyocytes
Identification and sequencing of CD36 interacting proteins in cardiomyocytes
ORGANISM(S): Mus Musculus 
2024-10-11 | PXD056711 |
ProteomicsQuantitative Proteome Profiling of Maize Root zones Provides Insight into the Proteins Associated with Enhance Water Uptake in Maize
In order to get a better understanding of protein functions related to water uptake in maize, we investigated the proteome dynamics of cv. Anyu308 root system at three key zones divided into Upper root (0cm-20cm), Middle root (20cm-40cm), and Lower root (40cm-60cm) by label-free quantitative shotgun...
ORGANISM(S): Zea Mays 
2021-05-26 | PXD026269 |
ProteomicsREGγ is essential to maintain bone homeostasis by degrading TRAF6, preventing osteoporosis
Primary osteoporosis, manifesting as decreased bone mass and increased bone fragility, is a “silent disease” that is often ignored until a bone breaks. Accordingly, it is urgent to develop reliable biomarkers and novel therapeutic strategies for osteoporosis treatment. Here, we identified REGγ as...
ORGANISM(S): Homo Sapiens 
2024-10-27 | PXD057237 |
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