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MetabolomicsTear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease
This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...
2026-04-04 | MTBLS14217 | MetaboLights
ProteomicsPutative methylomirabilis lanthanidiphila surface layer protein
Gambelli et al., 2021, investigate methylomirabilis bacteria, which perform anaerobic methane oxidation coupled to nitrite reduction via an intra-aerobic pathway to produce carbon dioxide and dinitrogen gas. These bacteria possess an unusual polygonal cell shape with sharp ridges that run along the...
ORGANISM(S): Candidatus Methylomirabilis sp. lanth 
2022-01-06 | PXD029319 | Pride
Qe plus Methylomirabilis lanthanidiphila Surface layer 
ProteomicsLactobacillus surface layer glycosylation
the project aims to provide a glycomic and glycoproteomic approach to reveal S-layer glycosylation on lactobacillus kefiri aggregating and non-aggregating strains
ORGANISM(S): Lactobacillus kefiri 
2020-08-24 | PXD020358 | Pride
Lactobacillus Glycosylation Glycopeptides S-layer 
GenomicsCharacterisation of Clostridium difficile surface layer proteins.
Whole genome sequencing to determine surface layer protein A (SlpA) gene sequence.
PRJEB6566 | ENA
GenomicsClostridium difficile surface layer protein sequence investigation.
Whole genome sequencing to determine surface layer protein A (SlpA) gene sequence.
PRJEB6286 | ENA
TranscriptomicsSpatiotemporal embryonic transcriptomics reveals the evolutionary history of the endoderm germ layer
The germ layer concept has been one of the foremost organizing principles in developmental biology, classification, systematics and evolution for 150 years. Of the three germ layers, the mesoderm is found in bilaterian animals but is absent in species in the phyla Cnidaria and Ctenophora, which has ...
ORGANISM(S): Caenorhabditis elegans 
2014-12-11 | E-GEOD-50548 | biostudies-arrayexpress
MetabolomicsMetabolic Remodeling of Soil Ecosystems by the medicinal fungus Wolfiporia cocos: Bidirectional Feedback and Functional Consequences
Widely targeted metabolomics based on UPLC-MS/MS was performed to explore metabolic differences between two tissues of Wolfiporia cocos sclerotium. Samples include inner white tissue (Fuling Bai) and outer layer (Fuling Pi) of sclerotium, with 3 biological replicates for each group. A total of 1565 ...
2027-08-10 | MTBLS15360 | MetaboLights
TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsReduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how loss of CFTR first disrupts airway host defen...
ORGANISM(S): Sus scrofa 
2012-03-29 | E-GEOD-36906 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor mutant unable to erect aerial hyphae identifies a previously unknown layer of erial mycelium surface proteins (the "chaplins")
The filamentous bacterium Streptomyces coelicolor differentiates by forming specialized, spore-bearing aerial hyphae that grow into the air. Using microarrays, we identified genes that are down-regulated in a mutant unable to erect aerial hyphae. Through this route, we identified a previously unkno...
ORGANISM(S): Streptomyces coelicolor 
2007-06-11 | E-SMDB-4093 | biostudies-arrayexpress
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