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ProteomicsTMPRSS2-mediated coronavirus spike activation and inhibition
The human protease TMPRSS2 facilitates entry of many respiratory viruses into cells, including coronaviruses and influenza viruses, yet its mechanism or viral glycoprotein recognition remains unclear. Here, we show that following ACE2 engagement and formation of an early fusion intermediate SARS-CoV...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD069687 | Pride
Sars-cov-2 
ProteomicsRevisiting the effect of trypsin digestion buffers on artificial deamidation
Deamidation of asparagine and glutamine residues occurs spontaneously, accelerated by adjacent amino acid residues and influenced by pH, temperature, and incubation time. Standard proteolytic digestion induces significant deamidation, which is especially problematic in bottom-up proteomic studies. T...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-11 | PXD054603 | Pride
De-glycopeptides Chemical deamidation De-glycoproteomics 
ProteomicsSialoglycans on human T cells attenuate death programs executed through the Fas pathway
T cells are critical executors of adaptive immune functions and their persistence is tightly regulated. Part of this regulation relies on programmed cell death driven by the Tumour Necrosis Factor (TNF) receptor superfamily. The addition of glycans that terminate in the monosaccharide sialic acid (s...
ORGANISM(S): Homo sapiens (Human) 
2025-12-30 | PXD068522 | Pride
Immunology Glycobiology Sialic acid Apoptosis T cells 
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