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ProteomicsRegional differences in the small intestinal proteome of control mice and of mice lacking lysosomal acid lipase
Background: Despite recent studies investigating the involvement of single cells in regional differences of the small intestine (SI), the metabolic contribution of the duodenum, jejunum, and ileum to the overall intestinal metabolism is still unclear. Basic procedures and main findings: Using an unt...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD048378 | Pride
Metabolism Proteomics Lal Small intestine Macrophages 
ProteomicsOptic Atrophy 1 (OPA1) overexpression promotes dyslipidemia and atherosclerosis coupled to altered aortic VSMC function in LDL-R deficient mice
OPA1 (Optic Atrophy 1), a mitochondrial inner membrane protein involved in mitochondrial cellular metabolism, energy production, calcium homeostasis, and sterol and bile acids (BAs) synthesis. Mitochondria are plastic organelles continuously undergoing biogenesis, fusion, fission, and mitophagy. On ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD060450 | Pride
Mouse Proteomics 
ProteomicsDeletion of matrix metalloproteinase-12 improves energy metabolism and brown adipose tissue function in mice prone to develop cardiometabolic disease
Matrix metalloproteinase-12 (MMP12) is a proinflammatory protein secreted by macrophages. We have previously demonstrated that the genetic deletion of MMP12 in a cardiometabolic mouse model (low-density lipoprotein receptor-deficient (LdlrKO) mice fed a high-fat, sucrose- and cholesterol-enriched di...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD063623 | Pride
Cold exposure Untargeted proteomics Bat Mitochondrial processes Ldlr-deficient mice Mmp12 
UnknownDDASSQ: An open-source, multiple peptide sequencing strategy for label free quantification based on an OpenMS pipeline in the KNIME analytics platform.
Not available
S-EPMC8459258 | biostudies-literature
UnknownImpact of Asialoglycoprotein Receptor and Mannose Receptor Deficiency on Murine Plasma N-glycome Profiles.
Not available
S-EPMC10462831 | biostudies-literature
UnknownRegional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase.
Not available
S-EPMC7615810 | biostudies-literature
ProteomicsAsialoglycoprotein receptor subunit ASGR1a deficiency leads to cholesterol malabsorption in zebrafish on a high cholesterol diet
One of the major pathways to clear glycoproteins from circulation is via the liver-specific asialoglycoprotein receptor (ASGPR). Recently, loss of asialoglycoprotein receptor 1 (ASGR1), the major subunit of ASGPR in humans, was found to correlate with lower levels of plasma apolipoprotein B-containi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-09-07 | PXD078307 | Pride
Asgr1 Steatosis Cholesterol Liver Zebrafish 
UnknownMannose Receptor Deficiency Impacts Bone Marrow and Circulating Immune Cells during High Fat Diet Induced Obesity.
Not available
S-EPMC9784906 | biostudies-literature
UnknownASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE<sup>-/-</sup> mice.
Not available
S-EPMC11608471 | biostudies-literature
UnknownMonocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity.
Not available
S-EPMC9189020 | biostudies-literature
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