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The project aim was to describe proteomic changes in E. coli MG1655 strain after removal of oriC. Temperature-sensitive transcriptional repressor cI857 and its target promoter was used to control the expression of a serine recombinase from bacteriophage phiC31 (phiC31 integrase). cI857 is a temperat...
ORGANISM(S): Escherichia coli 
2021-12-15 | PXD029931 | Pride
A novel genetic switch we term SWITCHER
Genomics
SWITCHER self-integration into ROSA26 locus
Breast cancer stem cells (bCSCs) have been implicated in tumor progression and therapeutic resistance; however, the molecular mechanisms that define bCSC-state are unclear. We have performed concurrent human miRNome-wide gain- and loss-of-function screens to identify switcher miRNAs controling the c...
ORGANISM(S): Homo sapiens 
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