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MetabolomicsGut Microbiota–Derived Ergothioneine Alleviates Antipsychotic-Induced Synaptic and Cognitive Impairments

Background: Chronic use of antipsychotic drugs is associated with neuronal damage and cognitive impairment, potentially mediated by alterations in gut microbiota metabolites, although the specific metabolite involved remains unknown.

Objective: To identify the key metabolite responsible for...

2026-04-08 | MTBLS12751 | MetaboLights
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
UnknownDefects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits.
Not available
S-EPMC7584772 | biostudies-literature
TranscriptomicsOxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32870 | biostudies-arrayexpress
UnknownNeurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.
Not available
S-EPMC4191006 | biostudies-literature
ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
GenomicsNeuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease
Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease
PRJNA849203 | ENA
GenomicsEnhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
PRJNA1113999 | ENA
ProteomicsSearch for synaptic biomarkers of Alzheimer’s disease
As synapse degeneration is an early event in Alzheimer’s disease (AD) pathophysiology, a biofluid marker of synapse loss in living patients could be a surrogate marker of disease prognosis and therefore would be an excellent addition to the AD biomarker arsenal. With direct access to the brain inter...
ORGANISM(S): Homo Sapiens 
2019-01-10 | PXD012138 | panorama
ProteomicsImpaired aggrephagy,abnormal vesicular trafficking and cellular stress, lead to protein aggregation,neurodegeneration and synaptic dysfunction in cerebellar vermis of children and adults with idiopathic autism
Autism spectrum disorder (ASD) is a debilitating neurodevelopmental disorder with genetic and environmental etiologies involving several brain areas exhibiting abnormalities of cognition and social behavior. Previous work showed involvement of synaptic abnormalities in dorsolateral prefrontal cortex...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD061746 | Pride
Lc-ms/ms Proteomics Vermis Vesicular transport Human Cerebellum Autism Protein misfolding Asd Proteostasis Neurodegeneration 
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