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ProteomicsSynaptic Proteome of the Trisynaptic Circuit
Electrophysiological features of excitatory synapses vary widely throughout the brain, granting neuronal circuits the ability to decode and store diverse patterns of information. Synapses formed by the same neurons have similar electrophysiological characteristics, belonging to the same type. Howeve...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-25 | PXD052913 | Pride
Synapse Trisynaptic circuit Hippocampus Synaptic type proteome Mouse 
ProteomicsCortical layer 5 neuron-specific synaptic protein profiling suggests differential vulnerability to neurodevelopmental disorders
Pyramidal neurons in the cortex are embedded in distinct information processing pathways. Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons receive different input and project to distinct brain regions. The synaptic molecular signatures that define synaptic connectivity ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD046812 | Pride
Synaptic proteome Neurodevelopment Turboid 
ProteomicsSynaptic vesicle proteomics with age and in synucleinopathies
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD048771 | Pride
Synuclein Synaptic vesicle Mouse Age 
TranscriptomicsTranscription profiling and proteomic profiling of mouse hippocampus
We have correlated transciptomics, proteomics and toponomics analyses of hippocampus tissue of inbred C57/BL6 mice to analyse the interrelationship of expressed genes and proteins at different levels of organization. We find that transcriptome and proteome levels of function are highly conserved bet...
ORGANISM(S): Mus musculus 
2008-06-19 | E-GEOD-8239 | biostudies-arrayexpress
UnknownTemporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability.
Not available
S-EPMC8700124 | biostudies-literature
ProteomicsSynaptic Proteome from whole Hippocampus
Electrophysiological features of excitatory synapses vary widely throughout the brain, granting neuronal circuits the ability to decode and store diverse patterns of information. Synapses formed by the same neurons have similar electrophysiological characteristics, belonging to the same type. Howeve...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-25 | PXD052901 | Pride
Synapse Mouse Hippocampus 
UnknownSynaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins.
Not available
S-EPMC12647736 | biostudies-literature
ProteomicsAnalysis of human tau and age dependent changes in the synaptic and non-synaptic mitochondrial proteomes of the htau model of tauopathy
We investigated the effects of human tau on subcellular populations of the brain mitochondrial proteome in vivo using transgenic htau mice at ages preceding (5 months) and coinciding with (8 months) onset of tauopathy.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD030950 | Pride
Mitochondria Alzheimer's Synaptic Human Tau 
ProteomicsMass spectrometry analysis of synaptic proteome of adult Fmr1 KO and wild-type mice.
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in the adu...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043700 | Pride
Brain Synaptoneurosomes Fmr1 ko mice 
UnknownMapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins.
Not available
S-EPMC6313906 | biostudies-literature
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