Sort   by:  
 Page size 
MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
Synaptic vesicles are storage organelles for neurotransmitters in the pre-synaptic cytosol. When an action potential arrives at the pre-synaptic terminal, they fuse with the pre-synaptic membrane and neurotransmitters are released. In this project, we set out to study the protein interactions formed...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-09 | PXD020859 | Pride
Chemical cross-linking Mass spectrometry Protein networks Synaptic vesicles Synaptophysin Synaptobrevin-2 
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
ProteomicsMolecular architecture of individual synaptic vesicles
Synaptic vesicles (SVs) perform neurotransmitter uptake inside the presynaptic neuron and their delivery to the synaptic cleft. The molecular composition of SVs was investigated, largely by proteomic analysis and fluorescent microscopy, and a model of an average SV was proposed. However, structural ...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-17 | PXD045356 | Pride
Synaptic vesicles Sv Fusion Proteinasek Lumos Pk 
ProteomicsSynaptic vesicles that store monoamines and glutamate differ in protein composition
Neuromodulators such as monoamines assure essential brain functions but relatively little is known about their mechanism of release. While recent work has advanced our knowledge of active zone architecture in dopamine axons, release machinery within the synaptic vesicle (SV) remains poorly understoo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD073685 | Pride
Synaptic vesicles Tmt Vmat2 Dopamine release Vglut2 
Proteomicsmouse synaptic vesicles protein expression
The isolated synaptic vesicles/synaptosome for MS analysis
ORGANISM(S): Mus Musculus 
2024-01-19 | PXD048702 |
UnknownSV2B defines a subpopulation of synaptic vesicles.
Not available
S-EPMC11184983 | biostudies-literature
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
ProteomicsHidden Proteome of Synaptic Vesicles in the Mammalian Brain
current synapse proteomics are restricted to “average” composition of abundant synaptic proteins. Here we performed a subcellular proteomic workflow that could identify and quantify the deep proteome of synaptic vesicles purified from rat whole brain, including previously missing proteins present in...
ORGANISM(S): Rattus Norvegicus Albus 
2020-12-31 | PXD021549 | JPOST Repository
ProteomicsStructure and Topography of the Synaptic V-ATPase–Synaptophysin Complex
Synaptic vesicles are organelles with a precisely defined protein and lipid composition, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here, we discovered a well-defined interface between the synaptic vesicle V-ATPase and synaptophysin by in situ cryo-elect...
ORGANISM(S): Mus Musculus 
2024-06-04 | PXD052814 |
Sort   by:  
 Page size