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ProteomicsHuman PSP synaptoneurosome proteomics
Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048456 | Pride
Human Psp Brain Synaptoneurosome 
ProteomicsComparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), exacerbates synapse loss ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013753 | Pride
Alzheimer synapse apoe synaptoneurosome neurodegeneration 
ProteomicsProteome Profiling in the Rat Dorsal Striatum Synaptoneurosome Following Methamphetamine Exposure
We performed discovery-based proteomic profiling of synaptoneurosomes (SNs), subcellular fractions of brain tissue containing both pre- and post-synaptic components, isolated from the dorsal striatum of rats following methamphetamine (Meth) administration to investigate how methamphetamine exposure ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-19 | PXD066175 | Pride
Synaptoneurosome Proteomics Dorsal striatum Mass spectrometry Methamphetamine 
TranscriptomicsAlterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-ev...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73018 | biostudies-arrayexpress
UnknownThe synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol.
Not available
S-EPMC4334750 | biostudies-literature
ProteomicsSleep-wake cycles drive daily dynamics of synaptic phosphorylation
The circadian clock drives daily changes of physiology, including sleep-wake cycles, by regulating transcription, protein abundance and function. Circadian phosphorylation controls cellular processes in peripheral organs, but little is known about its role in brain function and synaptic activity. We...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-14 | PXD010697 | Pride
Synaptoneurosome Circadian Sleep Mass spectrometry Phosphorylation Easyphos Phosphoproteomics 
TranscriptomicsTranscription profiling of human Alzheimers disease patients to identify genes regulating synaptic function and neuroplasticity in incipient AD
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12685 | biostudies-arrayexpress
UnknownNoninvasive Brain Stimulation Enhances Memory Acquisition and Is Associated with Synaptoneurosome Modification in the Rat Hippocampus.
Not available
S-EPMC6900464 | biostudies-literature
ProteomicsHuman brain homogenate and synaptoneurosome proteomics
Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD047282 | Pride
Brain Psp Human Dia 
TranscriptomicsAlterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-ev...
ORGANISM(S): Mus musculus 
2016-09-01 | GSE73018 | GEO
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