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TranscriptomicsElucidating Host-Pathogen Interaction in Acute Systemic Candidiasis in a Mouse Model Using Genomic Approach
Candida species is a common fungus that had evolved as both commensal and opportunistic pathogen in humans. The rise in human morbidity and mortality caused by Candida species sparked an alarming concern. However, the thin line between commensalism and infection as well as the analysis of Candida h...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-16339 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
TranscriptomicsBlood Gene Expression Signatures Predict Invasive Candidiasis
Focusing on host response to infection, we utilized a murine model to develop a  blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia.  Validation of the signature was achieved in an independent cohort of mice. BALB/...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-20524 | biostudies-arrayexpress
ProteomicsProteomic analysis of Candida albicans after serial systemic infection in murine model
This study assessed proteomic profile of Candida albicans after serial systemic infection in a murine model. The animals were infected initially by wild-type C. albicans SC5314 (WT) with an inoculum of of 3.5x105 cells via lateral tail vein. Then, five days post-infection, the animals were euthanize...
ORGANISM(S): Candida albicans (Yeast) 
2019-07-01 | PXD012944 | Pride
Candida albicans Virulence Proteomics Mass spectrometry Systemic candidiasis Serial passage Host–pathogen interaction Lc-ms/ms 
TranscriptomicsResponse of Candida albicans towards a novel antifungal benzimidazole derivative
Fungal infections are a serious health problem in the clinic especially in the immunocompromised patient. Disease ranges from widespread superficial vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antimycotica are available,...
ORGANISM(S): Candida albicans 
2011-07-14 | E-GEOD-21622 | biostudies-arrayexpress
ProteomicsCharacterization of pathogenic Candida glabrata and their effectiveness against systemic candidiasis in BALB/c mice
Candida glabrata is a common opportunistic fungal pathogen of humans, with the emergence of resitant strains being of particulary concern. The cell wall associated and secretory proteins are intrinsically involved in vital functions during the fungal-host interactions. These proteins are responsible...
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2023-03-11 | PXD032928 | Pride
Lc-ms Mouse model Candida glabrata 
UnknownChitotriosidase Activity Is Counterproductive in a Mouse Model of Systemic Candidiasis.
Not available
S-EPMC8007879 | biostudies-literature
TranscriptomicsCombined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions [C. albicans]
The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding o...
ORGANISM(S): Candida albicans 
2016-11-18 | GSE83679 | GEO
TranscriptomicsTranscriptional response of Candida albicans to endothelial cells
Candida albicans is exposed to a different host environment during different site of infection. Thus, different virulence factors may be active during differenttypes of infection. However,little is known about the C. albicans genes that are required for the initiation and maintenance of candidiasis....
ORGANISM(S): Candida albicans 
2010-06-30 | E-GEOD-5344 | biostudies-arrayexpress
GenomicsCombined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions
Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions
PRJNA326689 | ENA
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