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ProteomicsProteome-wide map of targets of T790M-EGFR-directed covalent inhibitors
Idnetification of the off-targets of several third generation T790M specific inhibtors.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-11 | PXD007163 | Pride
Abpp H1975 Co1686 T790m Azd9291 
GenomicsGermline EGFR T790M and Lung Cancer Risk
Germline EGFR T790M and Lung Cancer Risk
PRJNA1372777 | ENA
GenomicsGermline EGFR T790M and Lung Cancer Risk
Germline EGFR T790M and Lung Cancer Risk
PRJNA1372778 | ENA
TranscriptomicsTranscription profiling of mouse EGFR mutants
We performed mRNA expression profiling of lung tumors from C/L858R, C/T790M, and C/L+T mice and from corresponding normal lung tissue. Experiment Overall Design: mRNA was extracted from pulverized lung samples using Trizol (Invitrogen) and then hybridized to MOE 430 2.0 chips (Affymetrix) using stan...
ORGANISM(S): Mus musculus 
2009-12-14 | E-GEOD-17373 | biostudies-arrayexpress
GenomicsIntegrative Profiling of T790M Negative EGFR Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities
We performed whole exome and transcriptome analysis of 59 first- and second-generation EGFR TKI resistant metastatic EGFR mutated patients to characterize and compare molecular alterations mediating resistance in T790M positive and negative disease. Transcriptomic analysis revealed ubiquitous loss o...
EGAS00001005389 | EGA
ProteomicsTKI-resistant T790M EGFR Mutation Rewired EGFR Translocation Routes through Switching Interactome in Non-Small Cell Lung Cancer
Epidermal growth factor receptor (EGFR) harboring active mutations, Del19 and L858R, are most common oncogenic mutations in in non-small cell lung cancer (NSCLC) patients. The preferred treatment at first line is tyrosine kinase inhibitor (TKI) administration while the TKI-resistance usually develop...
ORGANISM(S): Homo Sapiens (human) 
2023-05-31 | PXD034228 | JPOST Repository
Genomics3' UTR RNA-sequencing of human EGFR-mutant PC9 cells that were CRISPR engineered to additionally contain EGFR-mutations T790M and C797S
3' UTR RNA-sequencing of human EGFR-mutant PC9 cells that were CRISPR engineered to additionally contain EGFR-mutations T790M and C797S
PRJEB41845 | ENA
UnknownEGFR T790M: revealing the secrets of a gatekeeper.
Not available
S-EPMC5640399 | biostudies-literature
Transcriptomics3' UTR RNA-sequencing of human EGFR-mutant PC9 cells that were CRISPR engineered to additionally contain EGFR-mutations T790M and C797S
Lung adenocarcinoma PC9 cells were engineered to not only contain the driving EGFR-mutations, but also EGFR T790M and EGFR C797S that provide resistance to EGFR inhibitors.
ORGANISM(S): Homo sapiens 
2021-07-19 | E-MTAB-9887 | biostudies-arrayexpress
UnknownThe Presence of EGFR T790M in TKI-Naive Lung Cancer Samples of Patients Who Developed a T790M-Positive Relapse on First or Second Generation TKI Is Rare.
Not available
S-EPMC9320221 | biostudies-literature
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