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TranscriptomicsTacrolimus in diabetic nephropathy
Validation of predicted gene expression of human mesangial cells after 24h Tacrolimus stimulus Objective: To evaluate tacrolimus as therapeutic option for diabetic nephropathy (DN) based on molecular profile and network-based molecular model comparisons. Materials and Methods: We generated molecular...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-84908 | biostudies-arrayexpress
TranscriptomicsTacrolimus TK173 RPTEC
Confluent cultures of a human renal fibroblast cell line (TK-173) and a human renal proximal tubule epithelial cell line (RPTEC/TERT1) were treated with 10 micromolar tacrolimus (FK-506) for one and three days.
ORGANISM(S): Homo sapiens 
2012-01-01 | E-MTAB-778 | biostudies-arrayexpress
ProteomicsComparing nephrotoxicity of the calcineurin inhibitors, cyclosporine A and tacrolimus, identifies their differential effects within the renal compartments
Chronic calcineurin inhibitor (CNI) nephrotoxicity is a major drawback in current immunosuppressive regimens. Pathology includes vascular and tubulointerstitial alterations. Although still commonly in use, cyclosporine A (CsA) is increasingly exchanged for tacrolimus (Tac) for a more favorable clini...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-25 | PXD038546 | Pride
Kidney Calcineurin Cyclosporine a Nephrotoxicity Rat Tacrolimus Phosphoproteome 
TranscriptomicsCellular and Molecular Immune Profiles in Renal Transplant Recipients after Conversion from Tacrolimus to Sirolimus
Tacrolimus and Sirolimus are commonly used to maintain immunosuppression in kidney transplantation. However, their effects on immune cells and allograft molecular profiles have not been elucidated. Here we characterized the effects of Tacrolimus to Sirolimus conversion on frequency and function of ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-55998 | biostudies-arrayexpress
TranscriptomicsPrevention of acute liver failure
Aim of this project was the evaluation of the effect of flushing (intraportal and intraoperative) hepatic allografts with tacrolimus before transplantation. Group A was administered tacrolimus, 20ng/ml in 1500ml albumin solution; and Group B was administered only albumin solution. Wedge biopsie of t...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-25338 | biostudies-arrayexpress
TranscriptomicsVillard_deRham_0810
Effect or Tacrolimus or Cyclosporin on Neural progenitor cells (NPC) derived from human embryonic stem cells.
ORGANISM(S): Homo sapiens 
2014-07-01 | E-MTAB-2096 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline
We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional de...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22459 | biostudies-arrayexpress
GenomicsTacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation
Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation
PRJNA397918 | ENA
TranscriptomicsTacrolimus in diabetic nephropathy
Validation of predicted gene expression of human mesangial cells after 24h Tacrolimus stimulus Objective: To evaluate tacrolimus as therapeutic option for diabetic nephropathy (DN) based on molecular profile and network-based molecular model comparisons. Materials and Methods: We generated molecular...
ORGANISM(S): Homo sapiens 
2016-08-01 | GSE84908 | GEO
GenomicsGut Bacteria and Tacrolimus Metabolism in Transplant Recipients
Gut Bacteria and Tacrolimus Metabolism in Transplant Recipients
PRJNA1283291 | ENA
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