Sort   by:  
 Page size 
MetabolomicsPodophyllotoxin-induced nephrotoxicity via the microbiota-gut-kidney axis in SD rats based on the toxicological evidence chain (TEC) concept
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-25 | MTBLS14854 | MetaboLights
MetabolomicsHepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice
3,5,6-Trichloro-2-pyridinol (TCP) is a primary degradation product of chlorpyrifos and chlorpyrifos-methyl. TCP has longer half-life in soil and greater solubility in water than its parent compound, and cause wide contamination in environments. However, studies about the toxic effects of TCP are lim...
2017-05-05 | MTBLS275 | MetaboLights
TranscriptomicsMicroRNA profiling of rats with ochratoxin A nephrotoxicity
The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA. To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatme...
ORGANISM(S): Rattus norvegicus 
2014-06-01 | E-MTAB-2475 | biostudies-arrayexpress
TranscriptomicsGenomic-Derived Markers for Early Detection of Calcineurin Inhibitor Immunosuppressant–Mediated Nephrotoxicity
The use of calcineurin inhibitor (CI) immunosuppressants has significantly improved the early allograft survival rate in organ transplantation. However, CI therapy has been associated with chronic nephrotoxicity, which limits their long-term utility. In order to understand the mechanisms of the toxi...
ORGANISM(S): Rattus norvegicus 
2011-11-23 | E-GEOD-19366 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis of Nephrotoxicity Induced by Cephaloridine, a Representative Cephalosporin Antibiotic
Cephaloridine (CER) is a classical beta-lactam antibiotic that has long served as a model drug for the study of cephalosporin antibiotic-induced acute tubular necrosis. In the present study, we analyzed gene expression profiles in the kidney of rats given subtoxic and toxic doses of CER in order to...
ORGANISM(S): Rattus norvegicus 
2010-05-26 | E-GEOD-10034 | biostudies-arrayexpress
ProteomicsDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Kinase inhibitors (KIs) used in cancer therapeutics are associated with various side effects. One of the most significant adverse events that lead to discontinuation or modification of treatment is nephrotoxicity. We have identified BCR-ABL1 inhibitor dasatinib as a potential glomerular nephrotoxin ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-29 | PXD011761 | Pride
Podocyte  kidney  dasatinib  bcr-abl  nephrotoxicity  cytoskeleton  actin  biophysics 
GenomicsPolymyxin nephrotoxicity in kidney chip
Polymyxin nephrotoxicity in kidney chip
PRJNA508797 | ENA
ProteomicsComparing nephrotoxicity of the calcineurin inhibitors, cyclosporine A and tacrolimus, identifies their differential effects within the renal compartments
Chronic calcineurin inhibitor (CNI) nephrotoxicity is a major drawback in current immunosuppressive regimens. Pathology includes vascular and tubulointerstitial alterations. Although still commonly in use, cyclosporine A (CsA) is increasingly exchanged for tacrolimus (Tac) for a more favorable clini...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-25 | PXD038546 | Pride
Kidney Calcineurin Cyclosporine a Nephrotoxicity Rat Tacrolimus Phosphoproteome 
GenomicsBiomarkers for aristolochic acid nephrotoxicity
Biomarkers for aristolochic acid nephrotoxicity
PRJNA680917 | ENA
TranscriptomicsDifferential gene expression in mouse kidney following 72 hours of colistin exposure by Illumina WG-6_V2 array
Colistin sulfate (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity in humans in up to 33% of cases. Little is known regarding genes involved in colistin nephrotoxicity. A murine model o...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-46410 | biostudies-arrayexpress
Sort   by:  
 Page size