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MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
TranscriptomicsTaf1 isoform expression in mouse
Targeted primers for Taf1 transcript across different brain regions (cerebellum, cortex, hippocampus, striatum) and different mouse body regions (heart muscle spleen) in male and female. Long read sequencing performed on cDNA with nanopore sequencing.
ORGANISM(S): Mus musculus 
2025-12-05 | E-MTAB-15282 | biostudies-arrayexpress
GenomicsTaf1 isoform expression in mouse
Taf1 isoform expression in mouse
PRJEB91140 | ENA
TranscriptomicsHolo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
TFIID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID is more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and d...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-45873 | biostudies-arrayexpress
Genomicsp53 Chip-Seq in U2OS treated with UV
We report that TAF1 phosphorylates p53 at Thr55 on the p21 promoter and this phosphorylation leads to dissociation of p53 from the promoter. Indeed, ChIP-Seq analysis reveals p53 undergoes promoter dissociation at a global level after response to DNA damage, underscoring general nature of the regul...
ORGANISM(S): Homo sapiens 
2014-10-10 | E-MTAB-1988 | biostudies-arrayexpress
GenomicsTAF1 is critical for AE driven leukemogenesis [ATAC-seq]
TAF1 is critical for AE driven leukemogenesis [ATAC-seq]
PRJNA553502 | ENA
GenomicsTAF1 is critical for AE driven leukemogenesis [ChIP-seq]
TAF1 is critical for AE driven leukemogenesis [ChIP-seq]
PRJNA473828 | ENA
GenomicsTAF1 is critical for AE driven leukemogenesis [RNA-seq]
TAF1 is critical for AE driven leukemogenesis [RNA-seq]
PRJNA473831 | ENA
ProteomicsPROTAC-mediated degradation of TAF1 induces apoptosis in AML cells and inhibits tumor growth in vivo
The bromodomain-containing protein, TAF1 (TFII-250), is the largest component of the multiprotein assembly TFIID, a dynamic complex that serves as a general factor for transcription initiation. CRISPR and RNAi screens of pan cancer cell lines revealed TAF1 is broadly required for optimal cell growth...
ORGANISM(S): Homo sapiens (Human) 
2025-02-28 | PXD061282 | Pride
Taf1 Apoptosis Protein targeting chimera Acute myeloid leukemia 
ProteomicsSRRM4/nSR100 directs neuronal-specific microexon splicing of TAF1 mRNA involved in X-linked Dystonia-Parkinsonism
X-linked dystonia-parkinsonism is a neurodegenerative disease, which is caused by a SVA retrotransposon insertion within TAF1, gene encoding an integral component of the basal transcription factor TFIID. The SVA insertion has been shown to induce defects both in biosynthesis and in alternative splic...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD009905 | Pride
Co-immunoprecipitation Epidgenetics 
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