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ProteomicsProteomic analysis of human Sertoli cells-derived extracellular vesicles
We performed a proteomic analysis of EVs derived from human Sertoli cells, aiming to obtain the profiling of the proteins in these EVs to explore their possible roles in the development of testis.
ORGANISM(S): Homo sapiens (Human) 
2021-12-24 | PXD030640 | Pride
Extracellular vesicles Sertoli cells Spermiogenesis 
ProteomicsImmunoprecipitation-Mass Spectrometry (IP-MS) of SRPK1 in endothelial cells
To identify the E3 ubiquitin ligase responsible for the polyubiquitination of SRPK1, we performed immunoprecipitation (IP) using an anti-SRPK1 antibody or IgG control as well as endothelial lysates treated with PA and MG-132, followed by mass spectrometry analysis
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-30 | PXD062417 | Pride
Rat Endothelial cells Lc-ms/ms 
ProteomicsSpatiotemporally direct capturing global substrates of post-translational modifying enzymes in living cells
Methods for direct capturing global substrates of protein-modifying enzymes in living cells are with many challenges, and yet largely unexplored. Here, we report a strategy to directly capture substrates of protein-modifying enzymes via PTM-acceptor residue crosslinking in living cells, enabling glo...
ORGANISM(S): Escherichia Coli 
2023-02-22 | PXD040318 |
ProteomicsThe novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
Here, by state-of-the-art mass spectrometry-based quantitative proteomic technology, we systematically screened the potential neo-substrates of a novel thalidomide derived cereblon modulator CC-885.
ORGANISM(S): Homo Sapiens 
2020-01-11 | PXD017071 |
ProteomicsSpatial-region-resolved proteomic map reveals mechanism of COVID-19-associated heart injury
Coronavirus disease 2019 (COVID-19) induces diverse clinical manifestations accompanied by multi-organ dysfunction. Of these, heart complications are the most life threatening. Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drive systemic ...
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031249 |
UnknownConvalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.
Not available
S-EPMC8121538 | biostudies-literature
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