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ProteomicsDeubiquitinase OTULIN dampens RIG-I dependent type I IFN signaling by removing the linear ubiquitination from TRAF6
In this study, we observed a global increase in intracellular linear ubiquitination upon RNA viral infection, suggesting that linear ubiquitination may be a prerequisite for the initiation of antiviral innate immunity. Furthermore, using a combination of various cell lines and in vivo experiments, w...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD070809 |
ProteomicsShigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation
We demonstrate that OspC effectors enable S. flexneri to evade septin cage entrapment. Mechanistically, OspC catalyzes ADP-riboxanation of SEPT9 at Arg561, a critical site essential for stabilizing septin hetero-oligomers. Notably, ADP-riboxanation or mutation of Arg561 impairs septin polymerization...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070327 |
ProteomicsThe Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment
We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquito...
ORGANISM(S): Homo Sapiens 
2024-01-10 | PXD048447 |
ProteomicsSalmonella enterica Serovar Typhimurium transcriptional regulator STM0347 mediates Flagellar Phase Variation via Hin invertase
To elucidate the STM0347 regulon in S. Typhimurium, we performed a quantitative proteomic profiling of stm0347 deletion mutant, compared with its parental WT strain.
ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344 
2022-06-27 | PXD034943 |
ProteomicsRepression of EGLN1 activity by SET7-catalyzed methylation
Repression of EGLN1 activity by SET7-catalyzed methylation
ORGANISM(S): Homo Sapiens 
2022-03-08 | PXD032126 |
ProteomicsIdentification of IRF3 hydroxylation site
Identification of IRF3 hydroxylation site in cells
ORGANISM(S): Homo Sapiens 
2024-03-12 | PXD050566 |
ProteomicsThe Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Li...
ORGANISM(S): Mus Musculus 
PXD045477 |
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