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ProteomicsUrine EV Phosphoproteomics - Highly Efficient Phosphoproteome Capture and Analysis from Urinary Extracellular Vesicles
Capture of urinary EVs with EVtrap and analysis of their phosphoproteome
ORGANISM(S): Homo sapiens (Human) 
2018-08-10 | PXD010480 | Pride
Exosomes Urine Evs Evtrap Phosphoproteomics 
ProteomicsSystematic Identification of SHP2 Phosphatase Substrates
Phosphatases play essential roles in normal cell physiology and diseases like cancer. The challenges of studying phosphatases have limited our understanding of their substrates, molecular mechanisms, and unique functions within highly complicate networks. Here we introduce a novel strategy using sub...
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD028404 | Pride
Phosphoproteomics Tyrosine phosphatase substrates Lc-ms Shp2 
ProteomicsIdentification of Direct Upstream Kinases by Fluorescence Complementation Mass Spectrometry
Kinase-substrate networks are the main components of many signal transduction pathways. Although proteome-wide studies have been successful in elucidating many important biological events including the cataloging of thousands of sites of protein phosphorylation, there is a lack of a universal method...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD004739 | Pride
Fcms Kinases Fluorescence complementation Phosphorylation 
ProteomicsPhosphoproteins in extracellular vehicles as candidate markers for breast cancer
The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins from biofluids for disease diagnosis remains elusive. Here we demonstrate, for the first time, a strategy to isolate and identify phosphoproteins in...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005214 | Pride
Plasma Extracellular vesicles Phosphoproteomics Biomarker 
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
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