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TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
ProteomicsTargeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer
Aberrant activation of the ERK signaling pathway triggers a protective anticancer response characterized by stable growth arrest and activation of tumor suppressors called cellular senescence. Pancreatic adenocarcinomas (PDAC) often possess mutations in K-Ras that activate the ERK pathway. Pancreati...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD032257 | Pride
Erk  pancreatic cancer  senescence  nucleolar stress  ribosome biogenesis  rna polymerase i 
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
UnknownTargeting Ribosome Biogenesis for Cancer Therapy with Oral Platinum Complexes.
Not available
S-EPMC11775699 | biostudies-literature
ProteomicsThe unphosphorylated form of the PAQosome core subunit RPAP3 binds ribosomal preassembly complexes to modulate ribosome biogenesis.
The PAQosome (Particle for Arrangement of Quaternary structure) is a twelve-subunit HSP90 co-chaperone involved in the biogenesis of several human protein complexes. Two mechanisms of client selection have previously been identified, namely the selective recruitment of specific adaptors and the diff...
ORGANISM(S): Homo sapiens (Human) 
2022-06-27 | PXD026647 | Pride
Ap-ms Ribosome preassembly factors Rpap3 Ribosome biogenesis Chaperone Ck2 phosphorylation Paqosome 
ProteomicsZNF574 is a Quality Control Factor Targeting Defective Ribosome Biogenesis Intermediates
The eukaryotic ribosome is a complex molecular machine responsible for the translation of mRNA to protein. Faulty ribosome production leads to decreased protein production, increased cellular stress, and often cell death. How defective ribosomes are detected and cleared is poorly understood. We mode...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD051645 | Pride
Proteomics Ribosome biogenesis Immunoprecipitation mass spectrometry (ip-ms) 
UnknownTargeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer.
Not available
S-EPMC10732607 | biostudies-literature
GenomicsPeroxisome import stress induces eIF2α phosphorylation and impairs ribosome biogenesis
Peroxisome import stress induces eIF2α phosphorylation and impairs ribosome biogenesis
PRJNA703841 | ENA
ProteomicsTargeting Fibrillarin-mediated ribosomal RNA maturation as a novel therapeutic vulnerability in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is among the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Current ribosome biogenesis inhibitors primarily tar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD060027 | Pride
Label-free quantitative proteomics Targeting ribosome biogenesis Nanolc-ms/ms Triple-negative breast cancer 
UnknownTargeting Ribosome Biogenesis to Combat Tamoxifen Resistance in ER+ve Breast Cancer.
Not available
S-EPMC8909264 | biostudies-literature
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