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ProteomicsC. elegans provide "milk" for their young
The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signaling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-reproductive animals continues, supported by destru...
ORGANISM(S): Caenorhabditis elegans 
2022-02-17 | PXD025472 | Pride
C. elegans Ageing Reproductive death Milk Yolk Semelparity 
ProteomicsPlasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-27 | PXD027747 | Pride
Transthyretin Heart Mouse Amyloidosis Tongue 
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
UnknownQuality of anticoagulation control in preventing adverse events in patients with heart failure in sinus rhythm: Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial substudy.
Not available
S-EPMC4439299 | biostudies-literature
UnknownDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Not available
S-EPMC9192715 | biostudies-literature
UnknownWarfarin and aspirin in patients with heart failure and sinus rhythm.
Not available
S-EPMC3723382 | biostudies-literature
UnknownAre large clinical trials in orthopaedic trauma justified?
Not available
S-EPMC5909275 | biostudies-literature
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.
Not available
S-EPMC6413805 | biostudies-literature
UnknownMeta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
Not available
S-EPMC5299468 | biostudies-literature
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