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ProteomicsThe proto-oncogene TCL1A deregulates mitotic checkpoint transition and genomic stability in CLL
Upregulation of the proto-oncogene TCL1A is causally implicated in various B- and T-cell malignancies. High-level TCL1A correlates with aggressive disease features and inferior clinical outcomes. However, molecular and cell-biological consequences of TCL1A dysregulation are not fully elucidated. Her...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD030776 | Pride
Tcl1a Leukemia Cdc20 Mitotic checkpoint Aneuploidy 
ProteomicsThe proto-oncogene TCL1A deregulates mitotic checkpoint transition and genomic stability in CLL
Upregulation of the proto-oncogene TCL1A is causally implicated in various B- and T-cell malignancies. High-level TCL1A correlates with aggressive disease features and inferior clinical outcomes. However, molecular and cell-biological consequences of TCL1A dysregulation are not fully elucidated. Her...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD030773 | Pride
Tcl1a Leukemia Cdc20 Mitotic checkpoint Aneuploidy 
GenomicsClonal hematopoiesis is driven by aberrant activation of TCL1A [ATAC-seq]
Clonal hematopoiesis is driven by aberrant activation of TCL1A [ATAC-seq]
PRJNA846750 | ENA
TranscriptomicsThe proto-oncogene TCL1A deregulates mitotic checkpoint transition and genomic stability in CLL
Upregulation of the proto-oncogene TCL1A is causally implicated in various B- and T-cell malignancies. High-level TCL1A correlates with aggressive disease features and inferior clinical outcomes. However, molecular and cell-biological consequences of TCL1A dysregulation are not fully elucidated. To ...
ORGANISM(S): Mus musculus 
2022-11-14 | GSE192409 | GEO
GenomicsClonal hematopoiesis is driven by aberrant activation of TCL1A [CITE-seq]
Clonal hematopoiesis is driven by aberrant activation of TCL1A [CITE-seq]
PRJNA846749 | ENA
GenomicsThe proto-oncogene TCL1A deregulates mitotic checkpoint transition and genomic stability in CLL
The proto-oncogene TCL1A deregulates mitotic checkpoint transition and genomic stability in CLL
PRJNA791361 | ENA
UnknownThe TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.
Not available
S-EPMC2718698 | biostudies-literature
UnknownAberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Not available
S-EPMC10360040 | biostudies-literature
GenomicsClonal hematopoiesis is driven by aberrant activation of TCL1A [ATAC-seq]
We used OMNI-ATAC to analyze the chromatin accessibility of TCL1A in TET2 edited HSPCs.
ORGANISM(S): Homo sapiens 
2022-12-20 | GSE205635 | GEO
TranscriptomicsClonal hematopoiesis is driven by aberrant activation of TCL1A [CITE-seq]
We used single cell RNA sequencing (scRNA-seq) to analyze the different cell populations present after in vitro culture of HSPCs with or without TCL1A overexpression.
ORGANISM(S): Homo sapiens 
2022-12-20 | GSE205636 | GEO
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