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UnknownNeoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia.
Not available
S-EPMC9667632 | biostudies-literature
UnknownInterpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy.
Not available
S-EPMC5632759 | biostudies-literature
ProteomicsImmunopeptidomics-guided warehouse design for peptide-based immunotherapy in chronic lymphocytic leukemia
In recent years the clinical success of T cell-based immunotherapy approaches has revolutionized treatment of solid tumors and hematological malignancies. However, still some patients do not respond to available therapies at all, others for limited time only. A promising low side-effect approach is ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024871 | Pride
Cll Hla Peptide warehouse Immunopeptidome 
ProteomicsA T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia
Runt-related transcription factor 1 (RUNX1) is a key regulator of hematopoietic differentiation. Disruption of RUNX1 in acute myeloid leukemia (AML) induces a maturation arrest and early myeloid progenitor phenotype. RUNX1 mutations occur in 10-15% of AML and are associated with poor prognosis. One-...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD062938 | Pride
Tcr-based immunotherapy Hla-peptidomics Runx1 Aml 
TranscriptomicsA novel nanobody-based TCR-like CAR-T therapy targeting PRAME for the treatment of acute myeloid leukemia
Chimeric antigen receptor (CAR) T-cell immunotherapy in acute myeloid leukemia (AML) remains challenging, primarily due to the lack of specific cell surface antigens that are highly expressed on leukemic blasts but largely absent on hematopoietic stem/progenitor cells and healthy tissues. TCR-like C...
ORGANISM(S): Homo sapiens 
2026-04-25 | GSE320438 | GEO
GenomicsA novel nanobody-based TCR-like CAR-T therapy targeting PRAME for the treatment of acute myeloid leukemia
A novel nanobody-based TCR-like CAR-T therapy targeting PRAME for the treatment of acute myeloid leukemia
PRJNA1428207 | ENA
TranscriptomicsPersonalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against metastatic ovarian cancer
Neoantigen-reactive cytotoxic T lymphocytes play a vital role in precise cancer cell elimination. In this study, we demonstrate the effectiveness of personalized neoantigen-based T cell therapy in inducing tumor regression in two patients suffering from heavily-burdened metastatic ovarian cancer. Ou...
ORGANISM(S): Homo sapiens 
2023-12-01 | GSE248401 | GEO
UnknownSpecific increase in potency via structure-based design of a TCR.
Not available
S-EPMC4205480 | biostudies-literature
TranscriptomicsMicroarray analysis of FoxP3-expressing or non-expressing subsets of human CD4+ T cells
Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. Abstract: FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15659 | biostudies-arrayexpress
UnknownTCR-based cellular immunotherapy for hepatocellular carcinoma: advances, challenges, and prospects.
Not available
S-EPMC12214192 | biostudies-literature
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