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ProteomicsProtein expression and oxidation in the hippocampus of neuronal nucleoredoxin knockout (Nestin-NXN-/-) versus floxed control mice (NXN-flfl)
Nucleoredoxin (NXN) is a thioredoxin-like member of the large group of redoxins which maintain redox balances in the cell. Its primary localization is the cytoplasm, and it is highly expressed in neurons. It has been described as a redox regulator of WNT signaling via maintenance of the redox balanc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024624 | Pride
Lc-ms/ms Hippocampus Redoxin Oxidoreductase Nucleoredoxin 
ProteomicsProteome of the cortex of old Pink1-SNCA A53T double mutant Parkinson mice
Parkinson's Disease (PD) is primarily caused by aggregates of alpha synuclein (SNCA) in dopaminergic neurons of the substantia nigra, but PD is a systemic disease and may lead to PD-associated dementia complex. PD-associated encephalopathy is a late manifestation in PD patients at risk for example o...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD039172 | Pride
Lc-ms/ms Mutant alpha synuclein (snca-a53t) Parkinson's disease Pten-induced kinase 1 Pd-associated encephalopathy 
ProteomicsProtein expression in the prefrontal cortex of aged mice with progranulin deficiency or neuronal progranulin overexpression
Description: Progranulin deficiency is associated with neurodegeneration in humans and in mice. We performed a deep proteomic screen of the pre-frontal cortex in aged (13-15 months) female progranulin-deficient mice (GRN-/-) and mice with a neuron-specific inducible overexpression of progranulin (SL...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-13 | PXD004087 | Pride
Lc-ms/ms Mice Cortex Progranulin Neurodegeneration 
TranscriptomicsIllumina Sentrix 6 mouse BeadChip gene expression analysis in mouse spinal cord in the EAE model of Multiple Sclerosis
The study assessed the efficacy of R-flurbiprofen in experimental autoimmune encephalomyelitis (EAE) models of multiple sclerosis in mice. R-flurbiprofen, also known as tarenflurbil, is the R-enantiomer of the cyclooxyygenase inhibitor S-flurbiprofen. It is ineffective in terms of cyclooxygenase inh...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-60847 | biostudies-arrayexpress
ProteomicsProtein expression in MOCK and neuronal nitric oxide synthase 1 (NOS1) transduced SH-SY5Y human neuroblastoma cells on stimulation with rapamycin or serum free starvation
Neuronal nitric oxide synthase (nNOS/NOS1) is upregulated in the aging brain and contributes to age-and stress-associated neuronal dysfunctions. To mimic this situation for the study of underlying mechanisms we generated a cell model in which human SH-SH5Y neuroblastoma cells constitutively express ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD010538 | Pride
Neuronal nos Starvation Rapamycin Sh-sy5y human neuroblastoma 
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