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ProteomicsProteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei
Telomeres are the nucleoprotein structures found at the ends of eukaryotic chromosomes. Conventional DNA polymerases are unable to fully replicate the telomeric end of the chromosome, which leads to a progressive loss of DNA after every cell division. This problem is solved by the ribonucleoprotein ...
ORGANISM(S): Trypanosoma brucei 
2023-03-08 | PXD038235 | Pride
Co-immunoprecipitation Telomerase Interaction partners Trypanosoma brucei Telomerase rna Lc-ms/ms 
TranscriptomicsTelomerase inhibitor TMPyP4 induced widespread gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes, analyzed across different cell-lines, was investigated Keywords: Comparative gene-expression profiling Cells were treated with TMPyP4 for 48 hours before RNA isolation. Untreated cells were...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-9710 | biostudies-arrayexpress
TranscriptomicsTelomerase inhibitor TMPyP4 induced gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course Cells were treated with TMPyP4 for either 24 or 48 hours before RNA isolation.Untreated cells were taken as controls and the TMPyP4 treated cells as tr...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-5226 | biostudies-arrayexpress
GenomicsGenome-wide TNFM-NM-1-induced p65 binding before and after telomerase inhibition in HeLa cells
Chromatin immunoprecipitation sequencing (ChIP-seq) was performed to analyze the effect of telomerase inhibition on TNFM-NM-1-induced genome-wide p65 binding in HeLa cells. By obtaining over 40 million uniquely mappable reads per sample from ChIP-seq, maps for TNFM-NM-1-induced p65 binding in absenc...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-41100 | biostudies-arrayexpress
ProteomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1
Telomere erosion contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive human cells to loss of telomere integrity, and uncovered a previously unannotated...
ORGANISM(S): Homo sapiens (Human) 
2021-03-04 | PXD022128 | Pride
C16orf72 Crispr-cas9 Genome-wide screen Telomere erosion P53 Telomerase inhibitor 
ProteomicsMudPIT analysis of S. pombe proteins interacting with Pof8
To identify proteins interacting with Pof8, cell-free extracts of strains FP1547 harboring 3xFLAG epitope-tagged Pof8 and untagged control (FP1546) were diluted to 5 mg/ml in 8 ml of lysis buffer (50 mM Tris-HCl pH 7.5, 150 mM sodium chloride, 0.1% (v/v) NP40 and 10% (v/v) glycerol) plus complete ED...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2021-05-24 | MSV000087493 | MassIVE
TranscriptomicsTelomerase inhibitor TMPyP4 induced gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course
ORGANISM(S): Homo sapiens 
2007-06-20 | GSE5226 | GEO
GenomicsTranscriptome-wide gene expression analysis of the cancer cell lines after treatiment with telomerase inhibitor Imetelstat (GRN163L)
Transcriptome-wide gene expression analysis of the cancer cell lines after treatiment with telomerase inhibitor Imetelstat (GRN163L)
PRJNA417570 | ENA
TranscriptomicsTelomerase inhibitor TMPyP4 induced widespread gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes, analyzed across different cell-lines, was investigated Keywords: Comparative gene-expression profiling
ORGANISM(S): Homo sapiens 
2008-08-25 | GSE9710 | GEO
TranscriptomicsTranscription profiling of human CD* T lymphocytes overexpressing hTERT
Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were performed on CD8 + naive T-cell clones isolated from two different healthy individuals aged between 30 to 35 years (HD1 a...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5143 | biostudies-arrayexpress
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