Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of Arabidopsis 3 week old plant leaves Overexpressing of TELOMERASE ACTIVATOR 1 (TAC1) vs controls
The goal of this investigation was to identify putative targets of the TELOMERASE ACTIVATOR 1 transcription factor. Experiment Overall Design: Total RNA was isolated from leaves of 3 week old plants. We used three biological replicates of wild type (Columbia) and the tac1-1D activation tagged line ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5896 | biostudies-arrayexpress
ProteomicsProteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei
Telomeres are the nucleoprotein structures found at the ends of eukaryotic chromosomes. Conventional DNA polymerases are unable to fully replicate the telomeric end of the chromosome, which leads to a progressive loss of DNA after every cell division. This problem is solved by the ribonucleoprotein ...
ORGANISM(S): Trypanosoma brucei 
2023-03-08 | PXD038235 | Pride
Co-immunoprecipitation Telomerase Interaction partners Trypanosoma brucei Telomerase rna Lc-ms/ms 
TranscriptomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
ProteomicsDisruption of ZC3H15 Compromises Telomere Length Maintenance by Sequestering Telomerase within Cajal bodies
Telomere homeostasis, crucial for various biological processes, relies on telomerase activity. We identified ZC3H15 as a novel telomerase-interacting protein. Its deletion unexpectedly increased telomerase activity but led to shortened telomeres and cellular senescence. ZC3H15 interacts with telomer...
ORGANISM(S): Homo Sapiens 
2024-05-06 | PXD052036 |
ProteomicsOptimization of an RNA-centric approach searching for RNA-interacting proteins in Arabidopsis thaliana
The number of methods used to study RNA-protein interactions in plants is currently relatively limited. The RNA-centric approach, starting with RNA of interest, brings several difficulties, especially when the RNA belongs to the less abundant RNAs. These methods for identification of RNA-interactin...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-22 | PXD046839 | Pride
Arabidopsis thaliana Telomerase Rna Rna-centric methods Rna-protein interactions Chirp-ms Telomerase rna Lc-ms/ms 
ProteomicsPartner of Yeast Telomerase TLC1 RNA (TLC1)
Identification of yeast telomerase protein composition.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-04-26 | PXD003273 | Pride
Yeast telomerase 
TranscriptomicsEvaluating the effects of cardiac telomerase re-activation after myocardial infarction in adult mice
Coronary heart disease is a main cause of death in the developed world and treatment success remains modest with high mortality rates within one year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary. Short telomeres are risk factors for age-assoc...
ORGANISM(S): Mus musculus 
2014-12-15 | E-GEOD-62973 | biostudies-arrayexpress
ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechan...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD002626 | Pride
Peroxiredoxin 1  telomeres  oxidative damage  telomerase 
ProteomicsMudPIT analysis of S. pombe proteins interacting with Pof8
To identify proteins interacting with Pof8, cell-free extracts of strains FP1547 harboring 3xFLAG epitope-tagged Pof8 and untagged control (FP1546) were diluted to 5 mg/ml in 8 ml of lysis buffer (50 mM Tris-HCl pH 7.5, 150 mM sodium chloride, 0.1% (v/v) NP40 and 10% (v/v) glycerol) plus complete ED...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2021-05-24 | MSV000087493 | MassIVE
Sort   by:  
 Page size