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TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [ChIP-Seq]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55155 | biostudies-arrayexpress
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [array]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55130 | biostudies-arrayexpress
ProteomicsThe Human Telomeric Proteome During Telomere Replication
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. In addition, recent evidence revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD018712 | Pride
Pot1 Telomeres Ipond Telomere fragility Histone h1 Qtip Dna replication 
GenomicsGenome-wide analysis reveals that budding yeast Rif1 binds to replication origins and at blocked replication forks to protect nascent DNA
This experiment details ChIP sequencing to decipher the binding sites of the Rif1 protein in budding yeast. Rif1 binds most strongly to telomeres where its binding is mediated by Rap1. To reduce telomere binding and help reveal Rap1-independent binding sites, a truncation mutant of Rif1 lacking the ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-31 | E-MTAB-6736 | biostudies-arrayexpress
TranscriptomicsTelomeric repeats facilitate CENP-A incorporation via telomere binding proteins
The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress
ProteomicsTRF1 averts chromatin remodelling, recombination and replication dependent-Break Induced Replication at mouse telomeres
Telomeric repeat sequences are prone to induce replication stress and one of the core telomere binding proteins, TRF1, is thought to counteract these problems. The molecular mechanisms coming into play upon TRF1 loss were not clearly defined though. This study combines an inducible TRF1 loss with te...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-22 | PXD017022 | Pride
Embryonic fibroblasts Lc-msms Teleomere Mus musculus Shelterin complex 
TranscriptomicsRif1 regulates the replication timing domains on the human genome
DNA replication is spatially and temporally regulated during S-phase. DNA replication timing is established in early G1-phase at a point referred to as TDP (timing decision point). We show that Rif1 (Rap1-interacting-factor1), originally identified as a telomere binding factor in yeast, is a critica...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-37971 | biostudies-arrayexpress
UnknownTRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres.
Not available
S-EPMC6986873 | biostudies-literature
UnknownBudding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro.
Not available
S-EPMC8191780 | biostudies-literature
UnknownDeregulated DNA ADP-ribosylation impairs telomere replication.
Not available
S-EPMC11102865 | biostudies-literature
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