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ProteomicsProteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates
The comprehensive profiling of the repertoire of secreted proteins from cancer cells and/or tissue samples provides information on the signaling events that take place during oncogenesis as well as on the cross-talk between normal and tumoral cells. Moreover, the analysis of post translational modif...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD010169 | Pride
Cancer Proteomics Keywords: secretome Tails Melanoma N-terminomics 
ProteomicsValidation of N-terminal Labeling Mass Spectrometry for Characterization of Partially Hydrolyzed Gluten Proteins
Gluten, a group of proteins found in wheat, barley, and rye, is the trigger of celiac disease, an immune disorder that affects about 1% of people worldwide. The toxicity of partially hydrolyzed gluten (PHG) in fermented products such as beer is unknown due to the significant analytical challenges in...
ORGANISM(S): Wheat 
2019-11-20 | PXD013679 | panorama
ProteomicsValidation of N-terminal Labeling Mass Spectrometry for Characterization of Partially Hydrolyzed Gluten Proteins
Gluten, a group of proteins found in wheat, barley, and rye, is the trigger of celiac disease, an immune disorder which affects about 1% of people worldwide. The toxicity of partially hydrolyzed gluten (PHG) in fermented products such as beer is unknown due to the significant analytical challenges i...
ORGANISM(S): Triticum aestivum (Wheat) 
2019-11-20 | PXD012296 | Pride
Hydrolyzed gluten  gluten  mass spectrometry  n-terminal labeling  tails 
ProteomicsVenom profiling of the insular species Bothrops alcatraz: characterization of proteome, glycoproteome, and N-terminome using Terminal Amine Isotopic Labeling of Substrates.
In this study we applied mass spectrometric approaches to characterize the proteome and glycoproteome of B. alcatraz venom, and to show for the first time the use of the TAILS method to profile a snake venom N-terminome.
ORGANISM(S): Bothrops alcatraz 
2021-01-13 | PXD021561 | Pride
Bothrops alcatraz  snake venom  proteome  glycoproteome  n-terminome  proteolytic processing 
ProteomicsDeveloping a Novel and Integrative Method to Systematically Investigate the Stability of N-Terminal Proteoforms
Protein N-terminal proteoforms, which include both N-terminal modifications and sequence variation arising from processes such as proteolytic cleavage, are common in cells and have been reported to significantly impact protein stability. Systematically examining the correlation between these N-termi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD057760 | Pride
Thermal proteome profiling N-terminal acetylation N-terminome Thermal stability difference Terminal amine isotopic labeling of substrates Tails Tpp N-terminal proteoform 
ProteomicsTAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-03 | MSV000088508 | MassIVE
ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
ProteomicsArabidopsis chloroplast N-terminome
Protein N-termini are prone to post translational modification and are major determinants of protein stability in bacteria, eukaryotes, and perhaps also in chloroplasts. Most chloroplast proteins undergo N-terminal maturation, but this is poorly understood due to insufficient experimental informatio...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2017-11-14 | MSV000081716 | MassIVE
ProteomicsIdentification of novel natural substrates of fibroblast activation protein by differential degradomics and proteomics (TAILS dataset)
Fibroblast Activation Protein (FAP) is a cell-surface transmembrane-anchored anchored dimeric protease. This unique constitutively active serine protease has both dipeptidyl aminopeptidase and endopeptidase activities, and can hydrolyse post-proline bonds. FAP expression is very low in adult organs,...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-19 | PXD004757 | Pride
Seprase Proteolysis 
ProteomicsThe distinct N-terminomes of Bothrops jararaca newborn and adult venoms.
In this study we applied the Terminal Amine Isotopic Labeling of Substrates (TAILS) technology to characterize the natural N-terminome of newborn and adult Bothrops jararaca venoms.
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2021-05-15 | PXD022696 | Pride
Bothrops jararaca  snake venom  n-terminome  proteolytic processing  tails. 
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