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Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways...
ORGANISM(S): Rattus norvegicus 
Muscle injury was elicited by cardiotoxin injection into the tibialis anterior muscle. Macrophages were isolated 2 days post-injury from the regenerating muscle. We used microarray to obtain global gene expression data of muscle-derived tissue macrophage subsets. Tissue macrophages were collected fr...
ORGANISM(S): Mus musculus 
Aging is characterized by a chronic, persistent and low-grade inflammatory response, and mitochondrial dysfunction plays an important role in inflammation in aging testes. Proteomic sequencing analysis of testicular mesenchymal exosomes showed differential expression profiles in young and aging test...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD049210 | Pride
Leydig cells (LCs) are the primary androgen producing cells in males throughout development and appear in chronologically distinct populations; fetal Leydig cells (FLCs), neonatal LCs and adult Leydig cells (ALCs). ALCs are responsible for progression through puberty and for maintenance of reproduct...
ORGANISM(S): Homo sapiens 
Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring pr...
ORGANISM(S): Homo sapiens 
Macrophage activation is required for the control of innate and adaptive immune responses. The classification in M1 and M2 macrophages based on a combination of small numbers of membrane and soluble markers is operational in murine and human macrophages. If this classification may be extended to cir...
ORGANISM(S): Homo sapiens 
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