Sort   by:  
 Page size 
TranscriptomicsGenome wide STAT3 RNAi expression profiling data from Thp,Th0 and Th17 cells
STAT3 is an immidiate regulator of Th17 differentiation. STAT3 difieciency downmodulate Th17 specific genes and Th17 responses. Therefore, we intend to identify genome wide targets of STAT3. We used microarrays to profile gene expression of STAT3 regulated genes during Th17 polarization. Total RNA w...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-67185 | biostudies-arrayexpress
ProteomicsCIP2A negatively regulates Th17 differentiation
Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010612 | Pride
Th17 cell differentiation Stat3 phosphorylation 
ProteomicsRole of Stat3 phosphorylation in Th17 differentiation
Determine the role of stat3 phosphorylation, particularly at S727, during the differentiation of Th17 cells.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-29 | PXD059588 | Pride
Th17 stat3 
TranscriptomicsRoles of STAT3 and STAT5 in regulation of gene expression under Th17 differentiation
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and ROR?t and inhibits Foxp3, IL-2 inhibited IL-1...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-26551 | biostudies-arrayexpress
TranscriptomicsGene array for identifying molecules involved in IL-10 regulation during Th17 polarization
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 pr...
ORGANISM(S): Mus musculus 
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress
GenomicsGenome-wide binding of STAT3 and STAT5 under Th17 conditions (ChIP-Seq)
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and RORγt and inhibits Foxp3, IL-2 inhibited IL-1...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-26552 | biostudies-arrayexpress
GenomicsGenome-wide detection of STAT3 binding sites in human Th17 cells
STAT3 is a major transcription factor driving the polarization of Th17 cells in response to IL-6, TGF-β and IL1-β. STAT3 is phosphorylated and forms a homodimer and translocates into the nucleus. There STAT3 binds to specific DNA sequences, regulating the transcription of its target genes. Here we...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-67183 | biostudies-arrayexpress
TranscriptomicsExpression data from regulatory T cells with Stat3 ablation
We used microarrays to detail the global programme of gene expression dependent upon Stat3 in regulatory T cells Regulatory T cells isolated from Foxp3 Stat3 or Foxp3 Stat3 were isolated using FACS based sorting followed by RNA extraction, amplification, labeling and...
ORGANISM(S): Mus musculus 
2009-09-04 | E-GEOD-17962 | biostudies-arrayexpress
GenomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity. Crucial for T helper17 (Th17) cells in vivo, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argued to ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23681 | biostudies-arrayexpress
ProteomicsDUSP2 dephosphorylates STAT3 at Y705 and S727 residues
In the related study, to determine whether DUSP2 definitively served as a phosphatase for STAT3, an in vitro phosphatase assay was used. Using S-tag beads, p-STAT3 was pulled down from IL-6 stimulated HEK293T cells transfected with STAT3-S-Tag. DUSP2 or control protein, which was purified from HEK29...
ORGANISM(S): Homo sapiens (Human) 
2015-10-13 | PXD002743 | Pride
Dusp2 Phosphorylation Stat3 
Sort   by:  
 Page size