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ProteomicsSuccinate mediates inflammation-induced adrenocortical dysfunction
Inflammation leads the hypothalamus-pituitary-adrenal (HPA) axis activation and increased production of glucocorticoids, which produced by the adrenal cortex, exert potent anti-inflammatory effects. The use of omics, including proteomics revealed metabolic changes in steroidogenic adrenocortical cel...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD036542 | Pride
Succinate Proteomics Tca cycle Lipopolysaccharide (lps) Adrenal gland Glucocorticoids 
ProteomicsSuspension TRAPping filter (sTRAP) sample preparation for quantitative proteomics in the low µg input range using a plasmid DNA micro-spin column: analysis of the hippocampus from the 5xFAD Alzheimer’s Disease mouse model
Suspension TRAPping filter (sTRAP) is an attractive sample preparation method for proteomics study. Here, we demonstrated the use of a low-cost Plasmid DNA spin column for sTRAP. We first evaluated, the reproducibility of this protocol and the low CoV using 4 replicates of 5-10 µg of a synapse enric...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-23 | PXD041045 | Pride
Alzheimer’s disease Proteomics 5xfad mouse model Micro-spin column Strap 
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