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ProteomicsT. gondii TIR1 strain temperature range thermal profiling experiment
Toxoplasma gondii is a single-celled eukaryotic parasite that chronically infects a quarter of the global population. In recent years, phenotypic screens have identified compounds that block parasite replication. Unraveling the complexity of pathogenesis and molecular mechanisms and pathways perturb...
ORGANISM(S): Toxoplasma gondii RH 
2023-03-11 | PXD024912 | Pride
Parasite Tpp Cetsa Toxoplasma 
ProteomicsExploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions
Denaturation-based assays such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA) are powerful tools for mapping global protein-protein interaction (PPI) networks. These workflows utilize different denaturation methods to probe PPIs, however, h...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD058773 | Pride
Human Tpca I-pisa Tpp 
UnknownMolecular mechanism for thermal denaturation of thermophilic rhodopsin.
Not available
S-EPMC6713869 | biostudies-literature
ProteomicsThermal proteome profiling of Toxoplasma gondii lysates treated with enhancer 1 (ENH1)
Previously, we characterized a chemical modulator, ENH1, that exhibited potent antiparasitic properties against apicomplexans and induced calcium oscillations, but the target eluded identification. To determine the target of ENH1, we employed thermal proteome profiling in parasites. We treated extra...
ORGANISM(S): Toxoplasma gondii GT1 
2020-07-13 | PXD018810 | Pride
Thermal proteome profiling Toxoplasma gondii Cetsa 
ProteomicsThermal proteome profiling of Toxoplasma gondii treated with enhancer 1 (ENH1)
reviously, we characterized a chemical modulator, ENH1, that exhibited potent antiparasitic properties against apicomplexans and induced calcium oscillations, but the target eluded identification. To determine the target of ENH1, we employed thermal proteome profiling in parasites. We treated extrac...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-21 | PXD018818 | Pride
Thermal proteome profiling Toxoplasma gondii Cetsa 
ProteomicsExploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions (Influenza A Data)
Denaturation-based assays such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA) are powerful tools for mapping global protein-protein interaction (PPI) networks. These workflows utilize different denaturation methods to probe PPIs, however, h...
ORGANISM(S): Homo sapiens (Human) Influenza A virus 
2026-02-02 | PXD068620 | Pride
Tpca Infuneza a 
UnknownDissociative mechanism for irreversible thermal denaturation of oligomeric proteins.
Not available
S-EPMC5418479 | biostudies-literature
ProteomicsThermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer
Cholesterol (CHOL) homeostasis is significantly modulated in prostate cancer (PCa) suggesting an active role in PCa development and progression. Several studies indicate a strong correlation between elevated CHOL levels and increased PCa risk and severity. Inhibition of CHOL biosynthesis at differen...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060338 | Pride
Next generation galeterone analog Cyp51a1 Thermal proteome profiling Cholesterol Prostate cancer Lanosterol synthase 
ProteomicsInvestigation of cellular response to the HSP90 inhibition in human cells through thermal proteome profiling
Heat shock proteins are responsible for protein folding in cells. HSP90 is one of the most important chaperones in human cells, and inhibiting HSP90 is a potential strategy for cancer therapy. Multiple HSP90 inhibitors have been in clinical trials. However, none of them has been approved for disease...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037575 | Pride
Heat shock protein 90 Hsp90 inhibitors And protein abundance change Thermal proteome profiling Cell response Protein thermal stability shift 
UnknownSequential events in the irreversible thermal denaturation of human brain-type creatine kinase by spectroscopic methods.
Not available
S-EPMC2920553 | biostudies-literature
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