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ProteomicsCytonuclear Fractionation TPCA in HSV-1 RF Infection
We developed a cytonuclear fractionated TPCA workflow, enabling the probing of global protein-protein interaction (PPI) networks with spatial resolution. We show that fractionation improves downstream PPI prediction, as well as increases the number of PPIs that can be detected. We apply this new wor...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 
2025-07-07 | PXD059014 | Pride
Human Tpca Subcellular fractionation Hsv-1 
ProteomicsExploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions (Influenza A Data)
Denaturation-based assays such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA) are powerful tools for mapping global protein-protein interaction (PPI) networks. These workflows utilize different denaturation methods to probe PPIs, however, h...
ORGANISM(S): Homo sapiens (Human) Influenza A virus 
2026-02-02 | PXD068620 | Pride
Tpca Infuneza a 
ProteomicsExploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions
Denaturation-based assays such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA) are powerful tools for mapping global protein-protein interaction (PPI) networks. These workflows utilize different denaturation methods to probe PPIs, however, h...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD058773 | Pride
Human Tpca I-pisa Tpp 
UnknownEnhancing the Treatment of Uncontrolled Inflammation through the Targeted Delivery of TPCA-1-Loaded Nanoparticles.
Not available
S-EPMC10609852 | biostudies-literature
ProteomicsTapioca – A Novel Platform for Prediction Of Protein-Protein Interaction Dynamics Identifies NUCKS1 as a Broad-Spectrum Herpesvirus Proviral Factor
Understanding protein-protein interaction (PPI) network dynamics is key to understanding nominal and perturbed cell states. Here, we develop a new machine learning framework called Tapioca that allows for the study of PPIs in dynamics contexts at a global scale in ex/in vivo conditions. Furthermore,...
ORGANISM(S): Human herpesvirus 8 strain GK18 Homo sapiens (Human) 
2025-05-06 | PXD041152 | Pride
Human Kshv Herpesvirus Thermal proximity coaggregation 
UnknownBreaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
Not available
S-EPMC4619123 | biostudies-literature
UnknownControlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling.
Not available
S-EPMC11541688 | biostudies-literature
UnknownTranscriptome‑based drug repositioning identifies TPCA‑1 as a potential selective inhibitor of esophagus squamous carcinoma cell viability.
Not available
S-EPMC9015666 | biostudies-literature
ProteomicsImproved in situ Characterization of Proteome-wide Protein Complex Dynamics with Thermal Proximity Co-Aggregation
Vast majority of cellular activities are carried out by protein complexes that assembled dynamically in response to cellular needs and environmental cues. Disarrayed cellular activities could arise from dysregulated protein complexes leading to diseases and developmental defects. Large scale efforts...
ORGANISM(S): Homo Sapiens 
2023-02-13 | PXD040078 |
ProteomicsIKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
Quantitative proteomic profiling of TPCA-1-treated bone marrow-derived macrophages stimulated with TNF-α (50 ng/mL) for 24 h. TNF-α was used as an endogenous pro-inflammatory stimulus and inducer of sterile inflammation.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036118 | Pride
Macrophages Tpca-1 Ikkβ Tnf-α 
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