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ProteomicsCytonuclear Fractionation TPCA in HSV-1 RF Infection
We developed a cytonuclear fractionated TPCA workflow, enabling the probing of global protein-protein interaction (PPI) networks with spatial resolution. We show that fractionation improves downstream PPI prediction, as well as increases the number of PPIs that can be detected. We apply this new wor...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 
2025-07-07 | PXD059014 | Pride
Human Tpca Subcellular fractionation Hsv-1 
UnknownEnhancing the Treatment of Uncontrolled Inflammation through the Targeted Delivery of TPCA-1-Loaded Nanoparticles.
Not available
S-EPMC10609852 | biostudies-literature
UnknownBreaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
Not available
S-EPMC4619123 | biostudies-literature
UnknownControlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling.
Not available
S-EPMC11541688 | biostudies-literature
ProteomicsTapioca – A Novel Platform for Prediction Of Protein-Protein Interaction Dynamics Identifies NUCKS1 as a Broad-Spectrum Herpesvirus Proviral Factor
Understanding protein-protein interaction (PPI) network dynamics is key to understanding nominal and perturbed cell states. Here, we develop a new machine learning framework called Tapioca that allows for the study of PPIs in dynamics contexts at a global scale in ex/in vivo conditions. Furthermore,...
ORGANISM(S): Human herpesvirus 8 strain GK18 Homo sapiens (Human) 
2025-05-06 | PXD041152 | Pride
Human Kshv Herpesvirus Thermal proximity coaggregation 
UnknownTranscriptome‑based drug repositioning identifies TPCA‑1 as a potential selective inhibitor of esophagus squamous carcinoma cell viability.
Not available
S-EPMC9015666 | biostudies-literature
ProteomicsIKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
Quantitative proteomic profiling of TPCA-1-treated bone marrow-derived macrophages stimulated with TNF-α (50 ng/mL) for 24 h. TNF-α was used as an endogenous pro-inflammatory stimulus and inducer of sterile inflammation.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036118 | Pride
Macrophages Tpca-1 Ikkβ Tnf-α 
TranscriptomicsHistone deacetylase 9 promotes vascular inflammation by activating IKK
Comparison of TNFα activated BMDM from B6.129P2-Apoetm1Unc/J mice treated with the inhibitors TMP195 or TPCA-1.
ORGANISM(S): Mus musculus 
2020-12-18 | GSE140783 | GEO
GenomicsGenome wide analysis of the effect of p65 inhibition upon the epigenomic landscape in high passage growth arrested cells being withdrawn from rapamycin
BJ Fibroblasts were maintained in rapamycin and were passaged until reaching growth arrest at very high passages. These cells were then maintained in or withdrawn from rapamycin, during which time they were given either control treatments or the p65 inhibitor TPCA-1.
ORGANISM(S): Homo sapiens 
2025-05-30 | GSE146582 | GEO
ProteomicsSystematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity
Rapid and dynamically shifting protein-protein interactions (PPIs) underlie the capacity of cells to recognize viral infections and ignite the downstream cascades that constitute the innate-immune response. Herpesviruses share an ancient history of coevolution with their hosts and have developed rec...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-05-11 | PXD023167 | Pride
Thermal proteome profiling  herpes simplex virus 1  protein complexes  protein interactions  ifi16  dna sensing  dna-pk  dna damage response  innate immunity 
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