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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
ProteomicsIntegrated changes in thermal stability and proteome abundance during altered growth and metabolic cell states.Integrated changes in thermal stability and proteome abundance during altered growth and metabolic cell states.
Altered thermal solubility measurement techniques are emerging as powerful tools to assess ligand binding, post-translational modification, protein-protein interactions, and many other cellular processes that affect protein state under various cellular conditions. Thermal solubility or stability pro...
ORGANISM(S): Escherichia coli 
2024-02-14 | PXD031800 | Pride
Pisa Thermal proteomic profiling 
ProteomicsThermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols
The dataset contains mass spectrometric raw data from Thermal Proteomic Profiling experiments aimed to identify the protein targets of three A- and B-ring oxidized sterols (cholestane-3beta,5alfa,6beta-triol (CT), 7keto-cholesterol (7-KC), 4beta-hydroxycholesterol (4beta-HC) ) and a side-chain oxidi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-16 | MSV000089661 | MassIVE
ProteomicsThermal proteome profiling in Cryptosporidium parvum
Cryptosporidium lacks tools that can identify the targets of emerging compounds that have been developed against this parasite. Thermal proteomic profiling is an unbiased approach that fulfils this unmet need by detecting changes in the thermal stability of target proteins upon the binding of their ...
ORGANISM(S): Cryptosporidium parvum Iowa II 
2023-06-13 | PXD037942 | Pride
Drug target Lysyl-trna synthetase Cryptosporodium parvum Thermal proteome profiling 
ProteomicsThermal Proteome Profiling (TPP) of l-Cysteine–Treated Arabidopsis Mitochondrial Proteins
This project investigates the thermal stability of isolated mitochondrial proteins from Arabidopsis thaliana cell cultures following L-cysteine treatment, using Thermal Proteome Profiling (TPP). Shotgun proteomics was employed to identify and quantify proteins after thermal treatment. Quantitative d...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-29 | PXD064096 | Pride
Thermal proteome profiling (tpp) Arabidopsis thaliana Mitochondria Melting temperatures Timstof-ht Shotgun proteomics Cell culture Melting curves 
MetabolomicsAROMA-GC: Green Automated Plasma Metabolome Profiling

Metabolomics enables the comprehensive profiling of low–molecular weight metabolites that reflect the interplay between environmental exposures and endogenous biological processes. As the downstream output of genomic, transcriptomic, proteomic, and epigenomic networks, the metabolome provides the...

2026-08-24 | MTBLS13319 | MetaboLights
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
ProteomicsThermal Proteome Profiling and Gut Microbiota-derived Bile Acids
Comprehensive thermal proteomic analyses was conducted to unravel and comprehend the protein targets affected by microbiota-derived bile acids in AD.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045381 | Pride
Lc-ms/ms Itraq Proteome profiling 
ProteomicsAssessing Target Specificity of the Small Molecule Inhibitor Marimastat to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro. The developmen...
ORGANISM(S): Crotalus atrox 
2024-06-22 | PXD046399 | Pride
Thermal proteome profiling Snake venom Metalloprotease 
ProteomicsProteomic profiling of thermal acclimation in Drosophila melanogaster
Proteomic response of adult Drosophila melanogaster acclimated at three contrasted thermal conditions (11, 25 and 31 degree Celsius) investigated by 2D-DIGE experiment. Thermal acclimation drastically alters thermotolerance of ectotherms, but the mechanisms determining this plastic response are not ...
ORGANISM(S): Drosophila (fruit flies) 
2013-03-04 | PXD000043 | Pride
Thermotolerance Acclimation Proteomics Fruit fly 
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