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ProteomicsPerformance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples
One of the major additions in mass spectrometry technology has been the irruption of the Orbitrap mass analyzer, which has boosted the proteomics analyses of biological complex samples since its introduction. Here we assessed the performance of the new generation Orbitrap Fusion Lumos Tribrid mass s...
ORGANISM(S): Homo sapiens (Human) 
2017-03-09 | PXD004940 | Pride
Protein quantitation Orbitrap fusion lumos Mass spectrometry Phosphorylation Protein identification 
MetabolomicsComposition of the marine exometabolome is more stable than the functionally redundant microbial community in the oligotrophic North Atlantic

Untargeted features from the Bermuda Atlantic Time-series Study (BATS) site collected during the time period spanning 2016 to 2019. Metabolites were sampled from surface seawater to 1000 m deep and throughout the year. Dissolved organic matter extracts were analyzed in positive and negative ion m...

2024-02-28 | MTBLS5228 | MetaboLights
MetabolomicsPhenomic and multiomic characterisation of microsatellite-stable colorectal cancer reveals novel biology and targets of vulnerability

Integrating data from approximately 2,000 tumour samples, corresponding to ~4,500 platform-specific multiomic sample profiles, and 195,246 single cells/nuclei from diverse in-house and publicly available datasets, single-to-integrated multiomic and clinical phenome data fusion analysis uncovers t...

2026-09-15 | MTBLS15127 | MetaboLights
ProteomicsProbing the Sensitivity of the Lumos Mass Spectrometer by analyzing varying amounts of whole cell extracts
PROJECT DESCRIPTION The Orbitrap Fusion Lumos mass spectrometer has recently been shown to have better fragmentation and detection than its predecessors. Previous studies using a HeLa digest analyzed on the Lumos mass spectrometer have reported the number of peptides and proteins identified by rever...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-04-19 | MSV000082296 | MassIVE
ProteomicsEvaluating cPILOT Performance on Orbitrap Instruments
A global cPILOT assay developed on an Orbitrap Velos instrument was transitioned to an Orbitrap Fusion Lumos instrument. Parameters such as the LC gradient, m/z isolation window, dynamic exclusion, targeted mass analyses, and SPS-N were optimized. The number of proteins identified on the Fusion Lumo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012133 | Pride
Proteomics Fusion lumos Alzheimer's disease Multiplexing Cpilot 
ProteomicsMouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
Liver sinusoidal endothelial cells (LSECs) from C57Bl/6J male mice obtained from Charles River Laboratory (Sulzfeld, Germany) were cultured on fibronectin coated plates in 5% oxygen atmosphere in AIM-V with serum-free supplements for 1h, 10h, or 48h. Data from quantitative proteomics using a tandem ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-25 | PXD041381 | Pride
Mus musculus Tmt sps ms3 method Orbitrap fusion lumos mass spectrometer 
ProteomicsProbing the Sensitivity of the Lumos Mass Spectrometer using a Standard Reference Protein in a Complex Background
we determined the sensitivity of the Lumos mass spectrometer using the NIST monoclonal antibody reference material at various concentrations to detect its peptides in a background of S. cerevisiae whole cell lysate, which was kept at a constant concentration.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-09-12 | PXD009441 | Pride
Data-dependent acquisition Orbitrap lumos Mass spectrometry Proteomics Limit of detection Sensitivity 
ProteomicsSARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition
Twenty microliter aliquots of BALF samples were dissolved in SDS-sample buffer and applied onto a 4-12% Nupage gel with MOPs running buffer. The run stopped after the samples migrated approximately ¼ distance into the gel. Each lane of the gel was sliced into smaller pieces, and subjected to destai...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD045119 | Pride
Nhbe cells Fibrin deposit Sars-cov-2 infection Bronchoalveolar lavage 
ProteomicsPoss_Pronobis BioID2 Zebrafish Interaction Proteomics
BioID2 Zebrafish Interaction Proteomics analyzed by nanoscale capillary LC coupled to a Fusion Lumos OT with label-free quantitation.
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-08-27 | PXD046501 | Pride
Bioid Interaction proteomics Lumos 
ProteomicsTET3 interaction proteomics in primary murine T cells. Tsagaratou UNC-CH
TET3 interaction proteoimcs +/- treatment, +/- IgG control. Label free quantitative proteomics on Fusion Lumos MS.
ORGANISM(S): Mus musculus (Mouse) 
2024-04-16 | PXD045465 | Pride
Interaction proteomics Tet3 Lumos 
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