Sort   by:  
 Page size 
MetabolomicsRedirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plast...

2021-06-24 | MTBLS2852 | MetaboLights
GenomicsGenome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation
Fertilization triggers a global erasure of 5-methylcytosine from paternal DNA as part of extensive epigenetic reprogramming during the transition from gametic specialization to totipotency. This active removal has been shown to involve oxidation by TET3, but the targeting of this pathway and the wid...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-63417 | biostudies-arrayexpress
ProteomicsTET3 interaction proteomics in primary murine T cells. Tsagaratou UNC-CH
TET3 interaction proteoimcs +/- treatment, +/- IgG control. Label free quantitative proteomics on Fusion Lumos MS.
ORGANISM(S): Mus musculus (Mouse) 
2024-04-16 | PXD045465 | Pride
Interaction proteomics Tet3 Lumos 
ProteomicsRedirected nuclear glutamate dehydrogenase supplies Tet3 with a-ketoglutarate in neurons
Tet3 is an Fe2+-dependent enzyme that oxidizes genomic 5-methylcytosine to 5-hydroxymethylcytosine with the help of alpha-ketoglutarate and oxygen. It is the most abundant Tet enzyme in differentiated tissues including brain. Adult brain contains the highest 5-hydroxymethylcytosine levels. How alpha...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-10 | PXD004518 | Pride
Citric acid cycle Epigenetics Alpha-ketoglutarate Oxaloacetate Tet3 Isocitrate Hmc 
GenomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RRBS]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61330 | biostudies-arrayexpress
TranscriptomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RNA-seq]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61329 | biostudies-arrayexpress
ProteomicsRest recruits neuronal Tet3 to induce chromatin remodeling and gene expression
Ten-eleven translocation (Tet) hydroxylases (Tet1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). In neurons increased 5hmC levels within gene bodies correlate positively with gene expression. The mechanisms controlling Tet activity and 5hmC levels are poorly understood. In part...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-02 | PXD001857 | Pride
Rest tet3 
TranscriptomicsEffect of TET1 and TET3 overexpression on the transcriptome of HEK293 cells
We compared TET1 and TET3 overexpressing cells to uninduced cells with endogenous levels of the respective transcript to determine global gene expression changes. TET1 overexpression, TET3 overexpression
ORGANISM(S): Homo sapiens 
2015-07-16 | E-GEOD-39186 | biostudies-arrayexpress
GenomicsTet3 regulates terminal cell differentiation at the metabolic level
Tet3 regulates terminal cell differentiation at the metabolic level
PRJNA719296 | ENA
GenomicsEffect of TET3 expression on muscle insulin sensitivity
Effect of TET3 expression on muscle insulin sensitivity
PRJNA929476 | ENA
Sort   by:  
 Page size