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TranscriptomicsRNA-sequencing uncovers transcriptomic changes in retinal tissues after vitreous substitution with a thermogelling polymer
We developed a thermogelling polymer with intrinsic anti-scarring properties on retinal cells in-vitro. To study its mechanism of action in-vivo, this thermogelling polymer was injected into the rabbit eye as a vitreous substitute and the retinal tissues were harvested for RNA-sequencing to understa...
ORGANISM(S): Oryctolagus cuniculus 
2022-04-09 | GSE200476 | GEO
GenomicsRNA-sequencing uncovers transcriptomic changes in retinal tissues after vitreous substitution with a thermogelling polymer
RNA-sequencing uncovers transcriptomic changes in retinal tissues after vitreous substitution with a thermogelling polymer
PRJNA824789 | ENA
ProteomicsDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocula...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-09-13 | PXD009525 | Pride
Eye Vitreous Thermogelling polymer Retinal detachment repair Rabbit 
TranscriptomicsRNA-sequencing uncovers transcriptomic changes induced by a multiblock thermogelling polymer on healthy and disease-modeled retinal pigment epithelial cells
Human embryonic stem-cell derived retinal pigment epithelial cells were co-stimulated with TNF-α and TGF-β1 to model a retinal scarring complication, proliferative vitreoretinopathy. Thermogelling polymer prevented this scarring complication. To understand the polymer-cell interaction and ultimately...
ORGANISM(S): Homo sapiens 
2022-03-09 | GSE176513 | GEO
GenomicsRNA-sequencing uncovers transcriptomic changes induced by a multiblock thermogelling polymer on healthy and disease-modeled retinal pigment epithelial cells
RNA-sequencing uncovers transcriptomic changes induced by a multiblock thermogelling polymer on healthy and disease-modeled retinal pigment epithelial cells
PRJNA736472 | ENA
UnknownControlled release of liraglutide using thermogelling polymers in treatment of diabetes.
Not available
S-EPMC4987673 | biostudies-literature
UnknownTemperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2-iso-butyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline)-Based Thermogelling Hydrogel.
Not available
S-EPMC6787588 | biostudies-literature
UnknownOptimization of Rheological Behaviour and Skin Penetration of Thermogelling Emulsions with Enhanced Substantivity for Potential Application in Treatment of Chronic Skin Diseases.
Not available
S-EPMC6723268 | biostudies-literature
UnknownPolymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.
Not available
S-EPMC8268746 | biostudies-literature
UnknownInjectable PTHF-based thermogelling polyurethane implants for long-term intraocular application.
Not available
S-EPMC9716749 | biostudies-literature
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