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TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-20 | E-MTAB-17207 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array to investigate the effect of interfacial stress on rat alveolar type II cell signalling and gene expression (conventional air-liquid interface)
Many epithelia have contact with air-liquid interfaces. This applies particularly to the lung, where one of the epithelial cell types (the surfactant secreting alveolar type II [AT II] cells) even project into the air. This specific environment may be of considerable physiological relevance; however...
ORGANISM(S): Rattus norvegicus 
2012-07-20 | E-MEXP-3363 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array to investigate the effect of interfacial stress on rat alveolar type II cell signalling and gene expression (inverted air-liquid interface)
Many epithelia have contact with air-liquid interfaces. This applies particularly to the lung, where one of the epithelial cell types (the surfactant secreting alveolar type II [AT II] cells) even project into the air. This specific environment may be of considerable physiological relevance; however...
ORGANISM(S): Rattus norvegicus 
2012-07-20 | E-MEXP-3372 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of immunoprecipitated NAA15-V5 variants
The human N-terminal acetyltransferase E (NatE) including its associated NatA co-translationally acetylates the N-terminus of about 40-60% of the proteome to mediate diverse biological processes including protein half-life, localization and protein interaction. In eukaryotes, the NatE complex contai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-13 | PXD017031 | Pride
Lc-ms/ms N-terminal acetylation Nate Naa15 Naa10 Hypk Naa50 
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
ProteomicsLC-MS/MS analysis of NAA15 and NAA10 IP
LC-MS/MS analysis of endogenous NAA15 and NAA10 immunoprecipitated from HeLa cell lysates was performed to identify cellular binding partners.
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD059724 | Pride
N-terminal acetylation Nata Naa15 Naa10 
TranscriptomicsMYC drives resistance to PI3K/mTOR targeted inhibition (Sty SNP array)
Genomic copy-number changes were measured using 250K StyI SNP arrays after selection of cells to enrich for resistance to BEZ235. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted using Qiagen DNeasy from engineered human cell-lines. Resulting alteratio...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25170 | biostudies-arrayexpress
TranscriptomicsmiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (microRNA)
MicroRNA (miRNA) expression profiling identified miR-638 as one of the most significantly overexpressed miRNAs in metastatic lesions compared with primary melanomas. miR-638 enhanced the tumourigenic properties of melanoma cells in vitro and lung colonization in vivo. mRNA expression profiling of mi...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-54492 | biostudies-arrayexpress
TranscriptomicsMYC drives resistance to PI3K/mTOR targeted inhibition (gene expression)
Gene expression signatures were measured after treatment of cells with 50nM BEZ235. Affymetrix HG-U133AV2 expression arrays were performed according to the manufacturer's directions using RNA extracted by Qiagen RNeasy from engineered human cell-lines grown for 72h in the presence of 50nM BEZ235 Res...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25172 | biostudies-arrayexpress
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
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