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ProteomicsGlobal Proteomic Analysis of Ovarian Clear Cell Carcinoma Cells Lacking ARID1A Reveals Upregulated Mitochondrial Electron Transport Chain Activity
Ovarian clear cell carcinoma (OCCC) is the most lethal gynecological cancer. It is characterized by somatic inactivating mutations of ARID1A, a component of the SWI/SNF chromatin-remodeling complex, occurring in up to 70% of patients. Patients with these mutations in their tumors have considerably p...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD050332 | Pride
Mitochondrial electron transport chain Mitochondria Arid1a Ovarian clear cell carcinoma 
ProteomicsEvaluation of the technical reproducibility of serum proteome sample preparation methods to support clinical proteomics applications
Evaluation of the efficiency and reproducibility of sample prepration methods using iST-BCT kit from PreOmics or SMART Trypsin Kit (Thermo Fisher) with in-house Rapigest protocol in human serum samples prior to mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD051002 | Pride
Serum  proteomics  biomarker  mass spectrometry  rapigest sf  ist-bct  smart digest trypsin 
ProteomicsOf mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer
- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD054649 | Pride
Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer 
ProteomicsProtein enrichment of human ascites fluid using Nanotrap hydrogel particle technology DIA
Compare protein and peptide identification, technical reproducibility, proteome depth, dynamic range, and gene ontology enrichment of ascites fluid. Enrichment will selectively isolate low abundance proteins and exclude high abundance proteins, enhancing depth of proteomic coverage.
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD076432 | Pride
ProteomicsProtein enrichment of human ascites fluid using Nanotrap hydrogel particle technology DDA
Compare protein and peptide identification, technical reproducibility, proteome depth, dynamic range, and gene ontology enrichment of ascites fluid. Enrichment will selectively isolate low abundance proteins and exclude high abundance proteins, enhancing depth of proteomic coverage.
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD068693 | Pride
ProteomicsInteractions of Histone Deacetylase 6 with DNA damage repair fac-tors strengthens its utility as a combination drug target in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy in women.The lack of effective second line therapeutics remains a substantial challenge for BRCA-1/2 wildtype HGSOC patients, and contributes to poor survival rates due to drug resistance. There is a striking need to el...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD044705 | Pride
Lc-ms Ovarian cancer Hdacs Protein-protein interaction Histone deacetylase 6 Human 
ProteomicsProteomic analysis reveals low dose PARP inhibitor-induced differential protein expression in BRCA1-mutated high-grade serous ovarian cancer cells
To detect the off-target effects of PARP inhibition, a quantitative mass spectrometry-based proteomic analysis was conducted of a BRCA1-mutated HGSOC cell line treated with low doses of two PARPi, Niraparib and Rucaparib.
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD027177 | Pride
Proteomics Ovarian cancer Mass spectrometry Tandem mass tags (tmt) Parp inhibitor (parpi) 
ProteomicsDifferential histone deacetylase inhibitor-induced perturbations of the global proteomic landscape in the setting of high-grade serous ovarian cancer
this project carried out a global mass spectrometry analysis in a panel of HGSOC cell lines analyzing proteomic perturbations following HDACi treatment
ORGANISM(S): Homo sapiens (Human) 
2022-11-04 | PXD036467 | Pride
High-grade serous ovarian cancer Histone deacetylase Histone deacetylase inhibitor 
ProteomicsReproducible Workflow for Multiplexed Deep-Scale Proteome and Phosphoproteome Analysis of Tumor Tissues by Liquid Chromatography-Mass Spectrometry

Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, Clauser KR, Clauss TR, Shah P, Gillette MA, et al., Nat Protoc. 2018 Jul 9. doi: 10.1038/s41596-018-0006-9

Here we present an optimized workflow for gl...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-30 | MSV000084265 | MassIVE
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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