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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
ProteomicsAorta proteomic analysis thoracic-abdominal
Aortic aneurysms is increasing as the human population ages. Pathological oxidative stress is implicated in development of aortic aneurysms. We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amin...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD060700 | Pride
Oxidative stress Vascular biology Chemogenetics Aneurysm 
TranscriptomicsMicroRNA profiling by array of Sus scrofa endothelial cells isolated from the athero-protective descending thoracic aorta and the athero-susceptible aortic arch
This study investigates the regional expression profiles of microRNAs (miRNAs) in endothelial cells isolated from the athero-protective descending thoracic aorta (DT) and from the athero-susceptible aortic arch (AA) in a swine model. Seven 2-channel assays comparing DT samples to AA samples were per...
ORGANISM(S): Sus scrofa 
2010-07-16 | E-CBIL-46 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat model of aging - progressive aortic vasculopathy
This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk fac...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7281 | biostudies-arrayexpress
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
TranscriptomicsInterference of PPAR gamma signaling in thoracic aorta
This SuperSeries is composed of the following subset Series: GSE37194: Gene expression profiling during interference with PPAR gamma signaling in thoracic aorta GSE37195: Gene expression profiling using exon arrays during interference with PPAR gamma signaling in thoracic aorta Refer to individual S...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-37196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse smooth muscle cells in atherosclerosis-prone and resistant regions of the aorta of C57Bl/6 mice at age of 4 months
This study compared gene expression in smooth muscle cells (SMCs) in atherosclerosis-prone and atherosclerosis-resistant regions of the aorta of C57Bl/6 mice. In a parallel experiment, both regions were compared in young, plaque-free apolipoprotein E-deficient (apoE-/-) mice. Aortas of 3 male and 3 ...
ORGANISM(S): Mus musculus 
2009-05-27 | E-GEOD-13835 | biostudies-arrayexpress
TranscriptomicsArterial vs venous expression of genes: differences in inflammatory genes
Arteries and veins modulate cardiovascular homeostasis and contribute to the pathogenesis of hypertension. Functional differences between normal arteries and veins are based upon differences in gene expression. To better characterize these expression patterns, and to identify candidate genes that ...
ORGANISM(S): Rattus norvegicus 
2009-07-13 | E-GEOD-12255 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse smooth muscle cells in atherosclerosis-prone and resistant regions of the aorta of apoE-/- mice at age of 4 months
This study compared gene expression in smooth muscle cells (SMCs) in atherosclerosis-prone and atherosclerosis-resistant aorta segments in 4 months old apolipoprotein E-deficient (apoE-/-) mice before plaque development. In a parallel experiment, both regions were compared in young C57Bl/6 mice. Aor...
ORGANISM(S): Mus musculus 
2009-05-27 | E-GEOD-13836 | biostudies-arrayexpress
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
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