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ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
ProteomicsMachine Learning Identifies Plasma Proteomic Signatures of Descending Thoracic Aortic Disease
Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict their risk of dissection or rupture. This study generated a plasma proteomic dataset from 150 patients with descending thoracic aort...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041337 | Pride
Plasma proteomics Machine learning Type b dissection Descending aortic disease Thoracic aortic aneurysm 
ProteomicsCDKL1 risk variants predispose to a connective tissue disorder with thoracic aortic aneurysm and dissection
Genetic factors are fundamental in the etiology of thoracic aortic aneurysm and dissection (TAAD), but the genetic cause is detected in only about 30% of cases. To define unreported TAAD-associated sequence variants, exome and gene panel sequencing was performed in 323 patients. We identified hetero...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD048044 | Pride
Cdkl1 Cgmp signaling Thoracic aortic aneurysm and dissection Arterial aneurysm and dissection Hereditary aortopathy Connective tissue disorder 
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
GenomicsExpression data from control, aortic aneurysm, and aortic dissection cells
Expression data from control, aortic aneurysm, and aortic dissection cells
PRJNA907394 | ENA
ProteomicsUnderstanding the role of TGFbeta signaling on aortic aneurysm and rupture using Marfan syndrome mouse models
Although abnormal TGFbeta signaling is observed in several heritable forms of thoracic aortic aneurysms and dissections including Marfan syndrome, the precise role of TGFbeta signaling in aortic disease progression is still disputed. Using a mouse genetic approach and quantitative isobaric labeling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD036222 | Pride
Mouse models Marfan syndrome Psr-ohsu Tgfbeta signaling Fibrillin Quantitative proteomics Aortic aneurysm and dissection Tandem mass tags 
GenomicNHLBI GO-ESP: Family Studies (Aortic Disease)

The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and relat...

phs000347 | dbGaP
UnknownHereditary Influence in Thoracic Aortic Aneurysm and Dissection.
Not available
S-EPMC5031368 | biostudies-literature
GenomicsNHLBI GO-ESP: Family Studies (Thoracic aortic aneurysms leading to acute aortic dissections)

The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and relat...

phs000347.v1.p1 | EGA
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