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ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064649 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064653 | Pride
Mitochondria Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064658 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction.
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064675 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsTEFM variants impair mitochondrial transcription elongation causing childhood-onset neurological disease
Mutations in either the mitochondrial or nuclear genomes are associated with a diverse group of human disorders characterized by impaired mitochondrial respiration. Within this group, an increasing number of mutations have been identified in nuclear genes involved in mitochondrial RNA biology. The T...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD030427 | Pride
Mitochondria Transcription Mitochondrial disease Rna 
ProteomicsUntargeted proteomics enables ultra-rapid variant prioritization in mitochondrial and other rare diseases
Only half of individuals with suspected rare diseases receive a definitive genetic diagnosis following genomic testing. A genetic diagnosis allows access to appropriate patient care and reduces the number of potentially unnecessary interventions and related healthcare costs. Here, we demonstrate tha...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD055473 | Pride
Human Fibroblasts Pbmcs Hek293t Orbitrap 
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownHigher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10156147 | biostudies-literature
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