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MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation, targeted lipid mediator profiling

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1381 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation, Targeted Phospho and Glycerolipid Profiling

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1369 | MetaboLights
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delinate Cysteinyl leukotrienes mode of action
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3589 | biostudies-arrayexpress
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation - DIA lipid mediator validation

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1382 | MetaboLights
TranscriptomicsTranslation State Array Analysis of Thrombin Stimulated Human Endothelial Cells
Confluent human umbilical vein endothelial cells (HUVECs) were exposed to Thrombin (2 U/mL) for 2 hours. Ribosomal profiling via gradient centrifugation and fractionation was used to separate monosome, or under-translated, and polysome, or actively translated, mRNA species that were then used to pr...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4919 | biostudies-arrayexpress
ProteomicsParadigm of biased PAR1 activation and inhibition in endothelial cells dissected by phosphoproteomics
Objective: Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of protease-activated receptors (PARs). The predominant thrombin receptor is PAR1 and in endothelial cells (ECs) thrombin dynamically regulates a plethora of phosphorylation events...
ORGANISM(S): Homo sapiens (Human) 
2017-08-22 | PXD004264 | Pride
Endothelial cells Par1-inhibitors Silac Par1 Thrombin Phosphoproteomics 
GenomicsIdentification of novel gene expression programs in thrombin-stimulated hepatic stellate cells
Identification of novel gene expression programs in thrombin-stimulated hepatic stellate cells
PRJNA1328649 | ENA
TranscriptomicsTranslation State Array Analysis of Thrombin Stimulated Human Endothelial Cells
Confluent human umbilical vein endothelial cells (HUVECs) were exposed to Thrombin (2 U/mL) for 2 hours. Ribosomal profiling via gradient centrifugation and fractionation was used to separate monosome, or under-translated, and polysome, or actively translated, mRNA species that were then used to pro...
ORGANISM(S): Homo sapiens 
2006-05-31 | GSE4919 | GEO
ProteomicsHuman platelet LC-MSMS
The phosphorylation status of Dab2 and its functional consequences in thrombin-stimulated human plateletswere investigated.
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD006337 | Pride
Lc-msms Disabled-2 Thrombin stimulation Human platelet 
TranscriptomicsIdentification of novel gene expression programs in thrombin-stimulated hepatic stellate cells
Transcriptional alterations of cultured hepatic stellate cells following 4, 24, or 48h control- or thrombin-stimulation were determined using RNA Sequencing. Illumina NovaSeq PE150 was used for sequencing.
ORGANISM(S): Homo sapiens 
2025-11-05 | GSE308047 | GEO
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