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ProteomicsiTRAQ based proteomic analysis to reveal the mechanism of tigecycline resistance in Acinetobacter baumannii
The antibiotic resistance of A. baumannii has been increasing in recent years. There are still many questions unclear concerning the mechanism of tigecycline resistance in A. baumannii. iTRAQ based proteomic analysis were used to reveal the mechanism of tigecycline resistance in Acinetobacter bauman...
ORGANISM(S): Acinetobacter baumannii 
2023-07-20 | PXD034784 | Pride
Acinetobacter baumannii Itraq Tigecycline resistance 
MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
MetabolomicsMetabolome and transcriptome combined profiling reveals fluconazole resistance mechanisms of Trichosporon asahii and role of farnesol in fluconazole tolerance

Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few studies have explored the underlying mec...

2023-11-20 | MTBLS7236 | MetaboLights
ProteomicsProteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides
Proteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides
ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Hs11286 
2022-01-17 | PXD031030 |
UnknownOvercoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.
Not available
S-EPMC11701230 | biostudies-literature
UnknownEmergence of tigecycline resistance in Escherichia coli co-producing MCR-1 and NDM-5 during tigecycline salvage treatment.
Not available
S-EPMC6239116 | biostudies-literature
TranscriptomicsThe Transcriptomic Signature of Tigecycline in Acinetobacter baumannii
Tigecycline, a protein translation inhibitor, is a treatment of last resort for infections caused by the opportunistic multidrug resistant human pathogen Acinetobacter baumannii. However, strains resistant to tigecycline were reported not long after its clinical introduction. Translation inhibitor a...
ORGANISM(S): Acinetobacter baumannii 
2020-08-03 | GSE131451 | GEO
UnknownPlasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli.
Not available
S-EPMC6707864 | biostudies-literature
ProteomicsThe mechanism of tigecycline resistance in Acinetobacter baumannii under sub-minimal inhibitory concentration tigecycline
The mechanism of tigecycline resistance in Acinetobacter baumannii under sub-minimal inhibitory concentration tigecycline by comparative protemics
ORGANISM(S): Escherichia Coli 
2024-01-26 | PXD048947 |
UnknownPotential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.
Not available
S-EPMC4750697 | biostudies-literature
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