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ProteomicsAlternative mRNA splicing controls functions of the human H3K27 demethylase UTX/KDM6A
The UTX/KDM6A gene encodes the UTX histone H3K27 demethylase, which plays an important role in mammalian development and is frequently mutated in cancers and particularly, in urothelial cancers. Using BioID technique, we explored the interactome of different UTX isoforms.
ORGANISM(S): Homo sapiens (Human) 
2024-01-28 | PXD041254 | Pride
Isoforms Kdm6a Bladder cancer 
ProteomicsMulti-omics analysis of MEN1 missense mutations identifies disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional and chromati...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031928 | Pride
Greencut&run 
ProteomicsChaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit composition exist and several TFIID subunits are shared with other complexes, conveying intricate cellular decision making to control subunit allocation and functional assembly of this essential transc...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD011211 | Pride
Proteomics Crystal structure Tfiid Chaperonin cct 
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