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ProteomicsCPK3 phosphorylates SNC1-TIR LC-MSMS
Toll/interleukin-1 receptor (TIR) domain proteins are immune signaling components and function as NAD+-cleaving enzymes to activate defense responses. Activation of TIRs represses growth and drives cell death in plants and promotes axon degeneration in animals, but how plant TIRs are repressed remai...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-06-12 | PXD060014 | Pride
Lc-msms Cpk3 Snc1-tir 
GenomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [scRNA-Seq]
LPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [scRNA-Seq]
PRJNA1117037 | ENA
GenomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [RNA-Seq]
LPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [RNA-Seq]
PRJNA1117034 | ENA
ProteomicsSNC1 phosphorylation sites invivo LC-MSMS
Toll/interleukin-1 receptor (TIR) domain proteins are immune signaling components and function as NAD+-cleaving enzymes to activate defense responses. Activation of TIRs represses growth and drives cell death in plants and promotes axon degeneration in animals, but how plant TIRs are repressed remai...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-06-12 | PXD060129 | Pride
Lc-msms Snc1 
UnknownSubstrate-induced condensation activates plant TIR domain proteins.
Not available
S-EPMC10972746 | biostudies-literature
UnknownMicrocrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly.
Not available
S-EPMC11394124 | biostudies-literature
TranscriptomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [scRNA-Seq]
Among the diseases caused by Toll-like receptor 4 (TLR4) abnormal activation by bacterial endotoxin, sepsis is the most dangerous one. The reprogramming of macrophages plays a crucial role in orchestrating the pathogenesis of sepsis. However, the precise mechanism underlying TLR4 activation in macro...
ORGANISM(S): Homo sapiens 
2024-08-01 | GSE268406 | GEO
TranscriptomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis [RNA-Seq]
Among the diseases caused by Toll-like receptor 4 (TLR4) abnormal activation by bacterial endotoxin, sepsis is the most dangerous one. The reprogramming of macrophages plays a crucial role in orchestrating the pathogenesis of sepsis. However, the precise mechanism underlying TLR4 activation in macro...
ORGANISM(S): Mus musculus 
2024-08-01 | GSE268405 | GEO
UnknownA genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins.
Not available
S-EPMC9440496 | biostudies-literature
UnknownBlocking TIR Domain Interactions in TLR9 Signaling.
Not available
S-EPMC6057823 | biostudies-literature
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