Tissue-specific aging

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Unknown (1985)
Genomics (435)
Transcriptomics (434)
Proteomics (94)
Methylation profiling (20)
Other (12)
Metabolomics (12)

Organisms

Mus musculus (259)
Homo sapiens (176)
Rattus norvegicus (32)
Drosophila melanogaster (21)
Caenorhabditis elegans (16)
Arabidopsis thaliana (6)
Macaca mulatta (4)
Nothobranchius furzeri (3)
Aedes aegypti (2)
Hordeum vulgare (2)
Triticum aestivum (2)
Danio rerio (2)
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Capsicum annuum (1)
Schmidtea mediterranea (1)
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Oryza sativa Japonica Group (1)
Canis lupus familiaris (1)
Sus scrofa (1)
Temnothorax rugatulus (1)

Organisms

Mus musculus (207)
Homo sapiens (84)
Drosophila melanogaster (14)
Rattus norvegicus (13)
Caenorhabditis elegans (10)
Temnothorax rugatulus (1)
Gerromorpha (1)
Heterocephalus glaber (1)
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Botryllus schlosseri (1)
Mus musculus musculus (1)
Aedes aegypti (1)
Macaca mulatta (1)
Danio rerio (1)
unidentified (1)
Sus scrofa domesticus (1)

Repository

ENA (379)
biostudies-arrayexpress (268)
geo (243)
pride (62)
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Tissue

Brain (25)
Heart (16)
Liver (15)
Kidney (13)
Lung (6)
Cell culture (4)
Skeletal muscle (4)
Skin (4)
Spleen (4)
Blood plasma (3)
Colon (3)
Epididymal white adipose tissue (3)
Adipose tissue (2)
Brown adipose tissue (2)
Muscle (2)
Posterior adductor muscle (2)
Abdominal adipose tissue (1)
Aorta (1)
Artery (1)
Biceps femoris (1)
Blood serum (1)
Breast (1)
Brown fat cell (1)
Cementum (1)
Dentin (1)
Esophagus (1)
Fat body (1)
Fibroblast (1)
Gut (1)
Intervertebral disc (1)

Disease

Alzheimer's disease (3)
Multiple sclerosis (1)
Temporal lobe epilepsy (1)
Obesity (1)
Adenocarcinoma (1)
Barrett's esophagus (1)
Cardiovascular system disease (1)
Glioblastoma (1)
Huntington Disease (1)
Lesion of sciatic nerve (1)

Technology Type

Mass Spectrometry (62)
Shotgun proteomics (28)
Bottom-up proteomics (17)
Data-dependent acquisition (15)
Mass spectrometry (10)
Data-independent acquisition (6)
Affinity purification coupled with mass spectrometry proteomics (5)
Top-down proteomics (3)
Mass spectrometry assay (2)
SWATH MS (2)
Illumina HumanMethylation450 (1)
NMR spectroscopy (1)
HDMSE (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (13)
Illumina HiSeq 2500 (7)
NextSeq 500 (4)
Illumina HiSeq 3000 (3)
Illumina HiSeq 4000 (3)
Orbitrap Fusion Lumos (3)
Controlled-environment growth chamber (short-day; 8 h light / 16 h dark) (2)
Illumina NovaSeq X (2)
Orbitrap Exploris 480 (2)
Orbitrap Fusion (2)
HISeq2500 (1)
Qiagen RNEasy Mini ki (1)
BD FACSAriaIIu cell sorter (1)
DNBSEQ Eukaryotic Stranded Transcriptome library preparation- Stranded mRNA Library (1)
Poly-T oligo-attached magnetic beads (1)
-- (1)
Covaris sonicator, PCR thermocycler, magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen mortar and pestle, benchtop microcentrifuge, vortex mixer (1)
Dissecting tools, liquid nitrogen, −80 °C freezer (1)
Thermocycler; magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen grinding tools; benchtop centrifuge (1)
HP desktop (1)
Fluidics workstation (1)
Covaris, NEBNext Ultra II DNA library prep kit (1)
G2565AA DNA microarray scanner [Agilent] (1)
NA (1)
- (1)
N/A (1)
DNBSEQ-T7 (1)
Illumina MiSeq (1)

Publication Date

2026 (83)
2025 (55)
2024 (47)
2014 (43)
2013 (40)
2023 (39)
2015 (38)
2021 (33)
2022 (29)
2010 (28)
2012 (26)
2020 (23)
2016 (23)
2008 (23)
2011 (19)
2018 (17)
2017 (14)
2007 (12)
2019 (10)
2009 (10)
2005 (2)
2006 (1)
2004 (1)

UNIPROT ID/AC

10116.ENSRNOP00000001467 (2)
10116.ENSRNOP00000004127 (2)
10116.ENSRNOP00000007070 (2)
10116.ENSRNOP00000007645 (2)
10116.ENSRNOP00000010798 (2)
10116.ENSRNOP00000019755 (2)
10116.ENSRNOP00000028732 (2)
10116.ENSRNOP00000031360 (2)
10116.ENSRNOP00000050143 (2)
10116.ENSRNOP00000052803 (2)
10116.ENSRNOP00000054637 (2)
10116.ENSRNOP00000059667 (2)
10116.ENSRNOP00000060017 (2)
10116.ENSRNOP00000061650 (2)
10116.ENSRNOP00000064401 (2)
10116.ENSRNOP00000064646 (2)
10116.ENSRNOP00000065372 (2)
10116.ENSRNOP00000065625 (2)
10116.ENSRNOP00000065704 (2)
10116.ENSRNOP00000066126 (2)
10116.ENSRNOP00000066155 (2)
10116.ENSRNOP00000066428 (2)
10116.ENSRNOP00000067288 (2)
10116.ENSRNOP00000067711 (2)
1433B_RAT (2)
1433E_RAT (2)
1433F_RAT (2)
1433G_RAT (2)
1433T_RAT (2)
1433Z_RAT (2)

CHEBI ID

CHEBI:32816 (5)
CHEBI:30769 (5)
CHEBI:18012 (4)
CHEBI:30915 (4)
CHEBI:15428 (3)
CHEBI:17148 (3)
CHEBI:15741 (3)
CHEBI:16335 (3)
CHEBI:16027 (3)
CHEBI:24266 (2)
CHEBI:17992 (2)
CHEBI:26984 (2)
CHEBI:17553 (2)
CHEBI:33508 (2)
CHEBI:15846 (2)
CHEBI:17858 (2)
CHEBI:16856 (2)
CHEBI:15978 (2)
CHEBI:17138 (2)
CHEBI:4170 (2)
CHEBI:17050 (2)
CHEBI:28757 (2)
CHEBI:16750 (2)
CHEBI:15729 (2)
CHEBI:28842 (2)
CHEBI:17754 (2)
CHEBI:16610 (2)
CHEBI:16000 (2)
CHEBI:6650 (2)
CHEBI:28044 (2)

Metabolite Name

D-Glucose (3)
ATP (3)
Thymine (3)
ADP (3)
L-Histidine (3)
Dihydroxyacetone phosphate (3)
Creatinine (3)
Caffeine (3)
L-Tyrosine (3)
Hypoxanthine (3)
Pyruvic acid (2)
Nomilin (2)
Glabrone (2)
Galacturonic acid (2)
Ribitol (2)
Malate (2)
Sinensetin (2)
Isosakuranin (2)
D-Fructose (2)
Threonic acid (2)
Warfarin (2)
Naringenin (2)
3-Methyl-2-oxovaleric acid (2)
UDP (2)
AMP (2)
Glycine (2)
Phthalic acid (2)
Uracil (2)
Melibiose (2)
Epicatechin (2)

First Public Date

2026 (84)
2025 (56)
2024 (49)
2023 (38)
2014 (37)
2022 (31)
2021 (21)
2020 (19)
2017 (14)
2019 (11)
2018 (8)
2015 (6)
2016 (3)
2013 (2)

Study type

Transcription profiling by array (174)
RNA-seq of coding RNA (37)
Methylation profiling by array (16)
ChIP-seq (8)
Unknown experiment type (6)
Methylation profiling by high throughput sequencing (6)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Animal - High-throughput sequencing (2)
Transcription profiling by RT-PCR (2)
Comparative genomic hybridization by array (2)
DNA-seq (2)
Animal - One-color microarray (1)
Human - Single-cell sequencing (1)
High-throughput sequencing (1)
Human - One-color microarray (1)
ChIP-chip by array (1)
RNA-seq of total RNA (1)

Release Date

2025 (266)
2024 (229)
2023 (211)
2021 (207)
2022 (188)
2020 (174)
2019 (127)
2018 (114)
2017 (101)
2014 (95)
2016 (94)
2015 (84)
2013 (72)
2026 (53)
2010 (52)
2012 (51)
2011 (40)
2008 (35)
2009 (30)
2007 (17)
2006 (3)
2004 (2)
2005 (2)
2001 (2)
1999 (2)
2002 (1)
2000 (1)

Lab affiliation

Department of Animal and Poultry Sciences and the School of Neuroscience, Virginia Tech, Blacksburg, VA, USA (4)
Cleveland Clinic Lerner Research Institute Cardiovascular and Metabolic Sciences (3)
University of Liverpool (3)
Department of Chemistry and Biomolecular Chemistry, University of Wisconsin, Wisconsin, USA (2)
1) Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA, USA. 2) Department of Cell Biology, Harvard Medical School, Boston, MA, USA. (1)
1Department of Pathology, Dana-Farber/Harvard Cancer Center, PhD Program in Immunology, Harvard Medical School; Department of Laboratory Medicine, Boston Children's Hospital, Enders Research Building, Room 811, Boston, MA, 02115, USA (1)
Aging Institute, University of Pittsburgh School of Medicine/UPMC (1)
Ben-Gurion University (1)
BioGipuzkoa Health Research Institute, Stem Cells & Aging Group, Donostia-San Sebastián, 20014, Spain; Donostia University Hospital, Advanced Therapies Unit, Donostia-San Sebastián, 20014, Spain. (1)
CECAD Excellent in Aging Research Cluster of Excellence for Aging Research at the University of Cologne Joseph-Stelzmann-Straße 26 50931 Cologne (1)
CECAD Institut - University of Cologne Joseph-Stelzmann-Strasse 26 50931 Cologne Germany (1)
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA Department of Physiology, University of California, San Francisco, San Francisco, CA Chan Zuckerberg Biohub, San Francisco, CA (1)
Charité – Universitätsmedizin Berlin, Germany (1)
Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia. (1)
Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea (1)
Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne D-50931 Cologne, Germany. (1)
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R. China (1)
Department of Biochemistry and Molecular Genetics University of Virginia School of Medicine (1)
Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore (1)
Department of Genome Sciences, University of Washington (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic (1)
Department of Medicine, Knight Cardiovascular Institute, Oregon Health & Sciences University, Portland, Oregon, USA (1)
Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden Max Planck Institute for Biology of Ageing–Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden (1)
Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison (1)
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, US (1)
European Molecular Biology Laboratory (1)
Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.  National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA (1)
Harry Perkins Institute of Medical Research and 2ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, Nedlands, Western Australia 6009, Australia (1)
Harvard medical school (1)
Helmholtz Diabetes Center (1)

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Transcription profiling of rat heart and adipose tissue response to aging and caloric restriction in

Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using AffymetrixÂ® RAE 230...

ORGANISM(S): Rattus norvegicus

2008-06-15 | E-GEOD-6718 | biostudies-arrayexpress

Comprehensive Untargeted Metabolomics Dataset of Saccharomyces cerevisiae Aging-Associated Mutants and Yeast–Host Interactions in Drosophila melanogaster

Aging is a complex biological process influenced by genetic factors, environmental conditions, and interactions between organisms and their associated microbes. The budding yeast Saccharomyces cerevisiae and the fruit fly Drosophila melanogaster provide complementary model systems for investigati...

2026-09-04 | MTBLS15555 | MetaboLights

Tissue-specific dysregulation of DNA methylation in aging

The normal aging process is a complex phenomenon associated with physiological alterations in the function of cells and organs over time. Although an attractive candidate for mediating transcriptional dysregulation, the contribution of epigenetic dysregulation to these progressive changes in cellul...

ORGANISM(S): Rattus norvegicus

2010-05-01 | E-GEOD-17332 | biostudies-arrayexpress

Human Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains

There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...

ORGANISM(S): Homo sapiens

2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress

Human Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains

ORGANISM(S): Homo sapiens

2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...

ORGANISM(S): Mus musculus

2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell aging

Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfuncti...

ORGANISM(S): Mus musculus

2011-05-06 | E-GEOD-27686 | biostudies-arrayexpress

Transcription profiling of rat model of aging - progressive aortic vasculopathy

This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk fac...

ORGANISM(S): Rattus norvegicus

2008-06-15 | E-GEOD-7281 | biostudies-arrayexpress

Mitochondrial gene expression decline in aging is tissue-specific and independent of mitochondrial number

Aging is the progressive decline in organismal function that leads to an increased risk of multiple diseases and mortality. The molecular basis of this decline is unknown. Using quantitative PCR for mitochondrial mRNA from multiple tissues from the same animals, we found that the rate of change in m...

ORGANISM(S): Mus musculus

2015-07-03 | E-GEOD-12480 | biostudies-arrayexpress

Multi-omics insights into the formation mechanism of aging quality in white tea (Bai Mudan) during storage: integrating sensory evaluation, volatilomics, metabolomics, and metagenomics

White tea (WT) develops unique aged quality during long-term storage, characterized by progressive changes in sensory properties and chemical composition. However, integrated insights into the sensory, metabolites, and microbial contribution underlying this...

2025-11-18 | MTBLS13336 | MetaboLights

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