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ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Phospho-TMT analysis of TLK1)
PhosphoTMT experiment on HEK293T cells transiently transfected with either SFB-TLK1, SFB-TLK2, or siRNAs targeting TLK1, TLK2, or TLK1 and TLK2. Data represents 4 biological replicates.
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD047966 | Pride
Phosphoproteomics Tandem affinity purification Tousled-like kinases Phospho-tmt 
ProteomicsTLK1 phosphorylates human RAD54
TLK1 phosphorylates RAD54 at novel residues -T41, T59, T700
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037131 | Pride
Tlk1 Rad54 Phosphorylation 
GenomicsMutational analysis of TLK1 and MDM1
Mutational analysis of TLK1 and MDM1
PRJNA1106510 | ENA
ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Tandem Affinity Purification coupled to LC-MS/MS of SFB-TLK1 WT, 1-240, and D607A)
Tandem affinity purification of SFB-Tagged TLK1 Wildtype, TLK1 1-240, and TLK1 D607A from transiently transfected HEK 293T cells to try to identify possible TLK1 interactions. Data represent technical duplicates.
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD047964 | Pride
Tandem affinity purification Tousled-like kinases Lc-ms/ms 
ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Tandem Affinity Purification coupled to LC-MS/MS of SFB-TLK1 133-208 and 133-208 Y149A F150A)
Tandem affinity purification of HEK 293T cells transiently expressing SFB-TLK1 133-208 or SFB-TLK1 133-208 Y149A F150A to identify if TLK1 PIP box mutants can still interact with PCNA.
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD048215 | Pride
Tandem affinity purification Tousled-like kinases Lc-ms/ms 
OtherMutational analysis of TLK1 and MDM1
The Tousled-like kinases 1 and 2 (TLK1/TLK2) regulate DNA replication, repair and chromatin maintenance. TLK2 variants are associated with ‘Intellectual Disability, Autosomal Dominant 57’ (MRD57), a neurodevelopmental disorder (NDD) characterized by intellectual disability (ID), autism spectrum diso...
ORGANISM(S): Homo sapiens 
2024-04-30 | GSE266289 | GEO
GenomicsDe novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
PRJNA1006072 | ENA
UnknownTargeting the TLK1-MK5 Axis Suppresses Prostate Cancer Metastasis.
Not available
S-EPMC11988051 | biostudies-literature
TranscriptomicsDe novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
The Tousled-like kinases 1 and 2 (TLK1/TLK2) regulate DNA replication, repair and chromatin maintenance. TLK2 variants are associated with ‘Intellectual Disability, Autosomal Dominant 57’ (MRD57), a neurodevelopmental disorder (NDD) characterized by intellectual disability (ID), autism spectrum diso...
ORGANISM(S): Homo sapiens 
2023-08-18 | GSE241032 | GEO
UnknownTLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair.
Not available
S-EPMC10484734 | biostudies-literature
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