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MetabolomicsNano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis

Many patients are suffering from atherosclerosis without typical risk factors, which can cause severe cardiovascular complications. Trimethylamine N-oxide (TMAO), derived from gut microbes, is a key unconventional contributor to the development of atherosclerosis. Here we present a stra...

2025-10-25 | MTBLS12426 | MetaboLights
MetabolomicsHelicobacter pylori infection promotes TMAO accumulation through Escherichia coli enrichment with gut–liver circadian disruption and hepatic metabolic injury
Helicobacter pylori (H. pylori) infection is associated with metabolic dysfunction-associated steatotic liver disease, but the microbial changes and circadian disturbances accompanying distal hepatic injury remain unclear. In specific pathogen-free (SPF) mice exposed to dietary choline, H. pylori in...
2026-09-18 | MTBLS15673 | MetaboLights
ProteomicsAdipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing
Circulating trimethylamine N-oxide (TMAO) participates in the pathogenesis of cardio-metabolic diseases, with hepatic flavin-containing monooxygenase 3 (FMO3) originally regarded as the primary source of TMAO production. Here, we demonstrate that white adipose tissue (WAT) expressed FMO3 and its der...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-23 | PXD066391 | Pride
Macrophage Mouse Inflammasome Adipocyte Fmo3 Tmao 
MetabolomicsAnalysis the concentration of betaine, choline, TMA, TMAO and amino acids in plasma in Megalobrama amblycephala.
Not available
ORGANISM(S): Megalobrama amblycephala 
ST000982 | MetabolomicsWorkbench
TranscriptomicsMetabolic responses of the model archaeon Halobacterium sp. NRC-1 to oxygen limitation
As part of a comprehensive post-genomic investigation of the model archaeon Halobacterium sp. NRC-1, we used whole genome DNA microarrays to compare transcriptional profiles of cells grown anaerobically via arginine fermentation versus cells either respiring aerobically in the presence of oxygen or ...
ORGANISM(S): Halobacterium sp. NRC-1 
2012-11-06 | E-GEOD-38374 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse brain tissue to investigate the integrity of the blood brain barrier to trimethylamine N-oxide
In vivo work done to determine how trimethylamine N-oxide (TMAO) affects integrity of the blood-brain barrier. Wild-type male C57Bl/6 mice were injected with saline or TMAO (1.8 mg/kg in saline), and killed 2 h after injection. Mice were transcardially perfused with 0.9% saline at 4 °C to remove cir...
ORGANISM(S): Mus musculus 
2020-12-19 | E-MTAB-9869 | biostudies-arrayexpress
GenomicsGene expression levels after TMAO treatment
Gene expression levels after TMAO treatment
PRJNA560340 | ENA
TranscriptomicsTranscriptional changes in Escherichia coli during a shift from fermentation to Trimethylamine-N-oxide (TMAO) respiration
Gene-expression measurements were made over a 24 h time course as fermentative steady state E. coli cells were subjected to a shift to TMAO respiration.
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-12-13 | E-MTAB-2784 | biostudies-arrayexpress
GenomicsTMAO promoted TREM-1 expression through NLRP3 inflammasome
TMAO promoted TREM-1 expression through NLRP3 inflammasome
PRJNA1054027 | ENA
GenomicsTMAO treated human vascular smooth muscle cells
TMAO treated human vascular smooth muscle cells
PRJNA823056 | ENA
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