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GenomicsTMED10 regulates cell-surface expression of PD-1
TMED10 regulates cell-surface expression of PD-1
PRJNA675877 | ENA
TranscriptomicsTMED10 regulates cell-surface expression of PD-1
We found that Tmed10 regulates the cell-surface expression of PD-1 in T cells. We additionally show that treatment with AGN192403 can phenocopy Tmed10 KO by lysosomally degrading the Tmed10-PD-1 complex.
ORGANISM(S): Mus musculus 
2023-11-10 | GSE161211 | GEO
UnknownCoronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors.
Not available
S-EPMC11461611 | biostudies-literature
UnknownRAB21 interacts with TMED10 and modulates its localization and abundance.
Not available
S-EPMC6777364 | biostudies-literature
ProteomicsTMED10 INHIBITION SUPPRESSES CELL-SURFACE PD-1 EXPRESSION AND REVERSES T CELL DYSFUNCTION
PD-1 immune checkpoint blockade (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression. In a whole-genome, dual-marker FACS-based CRISPR/Cas9 screen in primary murine CD8 T cells, we found that inactivation of the EMP24/GP25L/p24 protein family, mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD026984 | Pride
Pd-1 Lc-ms T-cell dysfunction Melanoma Tmed10 
UnknownThe circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Not available
S-EPMC7160961 | biostudies-literature
UnknownTMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation.
Not available
S-EPMC10655563 | biostudies-literature
GenomicsTMED10 inhibition suppresses cell-surface PD-1 expression and overcomes T cell dysfunction
TMED10 inhibition suppresses cell-surface PD-1 expression and overcomes T cell dysfunction
PRJNA1063308 | ENA
UnknownA Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.
Not available
S-EPMC6580964 | biostudies-literature
TranscriptomicsTMED10 inhibition suppresses cell-surface PD-1 expression and overcomes T cell dysfunction
PD-1 immune checkpoint blockade (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression. In a whole-genome, dual- marker FACS-based CRISPR-Cas9 screen in primary murine CD8 T cells, we found that inactivation of the EMP24/GP25L/p24 protein family, m...
ORGANISM(S): Mus musculus 
2024-12-05 | GSE252956 | GEO
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