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GenomicsGCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway
PRJNA861993 | ENA
TranscriptomicsGCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway
To investigate the expression profilings after knocking out TMEM251. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different TMEM251 sgRNA knockout cells compared to WT
ORGANISM(S): Homo sapiens 
2022-07-28 | GSE209652 | GEO
UnknownMolecular Insights into the Regulation of GNPTAB by TMEM251.
Not available
S-EPMC11643035 | biostudies-literature
UnknownGCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Not available
S-EPMC9468337 | biostudies-literature
ProteomicsLYSET/TMEM251 KO and GNPTAB KO secretomes from MEFs
Analysis of proteins secreted over 24 h in OptiMEM by LYSET/TMEM251 knockout, GNPTAB knockout and wild-type MEFs
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD035822 | Pride
Mefs Lyset Secretome Tmem251 Gnptab 
ProteomicsThe human disease gene TMEM251 is essential for lysosomal transport and viral infection
After gaining access to the endo-lysosomal pathway, several viruses depend on lysosomal cathepsin proteases to cleave their structural proteins triggering productive entry. Targeting of cathepsins and other luminal lysosomal proteins to lysosomes requires their modification with mannose 6-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD029746 | Pride
Glycoproteomics Mannose-6-phosphate 
ProteomicsLYSET/TMEM251 SILAC Co-IP from MIA PaCA-2
Endogenous LYSET/TMEM251 was isolated via Co-IP from MIA PaCa-2 cells. LYSET KO cells were used as controls. Cells were grown in SILAC medium for 3 passages
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD035821 | Pride
Silac co-ip Human Lyset Tmem251 
UnknownTMEM251 loss-induced autophagy dysfunction in the anterior cingulate cortex contributes to chronic postoperative pain.
Not available
S-EPMC12796400 | biostudies-literature
ProteomicsLYSET/TMEM251 KO secretome from MIA PaCa-2 cells
Analysis of proteins secreted over 24 h in OptiMEM by LYSET/TMEM251 knockout and control MIA PaCa-2 cells.
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD029658 | Pride
Human Pancreatic cancer Secretome 
ProteomicsLYSET/TMEM251 KO cellular and lysosomal proteomes from MIA PaCa-2 cells
Proteome analysis of post-nuclear supernatants (PNS) and enriched lysosomal fractions from LYSET/TMEM251 knockout and control MIA PaCa-2 cells. Lysosomes were loaded with iron nanoparticles (DexoMAG C, Liquids Research). PNS were generated from cell homogenates and used as input to enrich lysosomal...
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD029659 | Pride
Pns Lysosomes Human Pancreatic cancer 
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